Congolese Medicinal Plant biodiversity as Source of AntiCOVID-19 Compounds: Economic goods in the light of Comparative Advantages Theory of Ricardo

Modeste Ndaba Modeawi, Ruphin Djolu Djoza, Colette Masengo Ashande, Clarisse Falanga Mawi, Emmanuel Moke Lengbiye, Clément Inkoto Liyongo, Benjamin Gbolo Zoawe, Muhammad Ridwan, Pius T. Mpiana, Mudogo Virima, Koto-te-Nyiwa Ngbolua

Abstract


Since the outbreak of Covid-19 (Corona virus) in China in December 2019, the disease has killed more people in Europa, America and Asia according to official sources.  Less impacted than the rest of the world, Africa as well as Oceania has less confirmed cases and less deaths. In countries whose health systems are among the most fragile in the world, with far less resources than those mobilized in Europe, China or the United States, the situation in Africa is potentially catastrophic. Since human and material resources, such as hospitalization and intensive care beds, are largely insufficient, the mortality rate linked to Covid-19 is likely to be 3 to 5 times higher than in the rest of the world. In the face of this evidence, scientific research based on medicinal plants would be seen as no less important part of the solution to the Covid-19 pandemic, based on plant biodiversity. The Malagasy Institute of Applied Research (IMRA/Madagascar) on the basis of the Artemisia annua has set up Covid-Organics; The Congolese plant biodiversity offers undeniable advantages for the setting up of an Improved Traditional Medicine following the example of Covid-Organics. This would constitute for the Democratic Republic of the Congo a comparative advantage to be put forward in its multiple international exchanges.


Keywords


COVID-19; plant biodiversity; phytomedicine; comparative advantage; Democratic Republic of the Congo

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Boozary, A., Farmer, P., & Jha, A. (2014). The ebola outbreak, fragile health systems, and quality as a cure. JAMA, 312(18), 1859‑1860. https://doi.org/10.1001/jama.2014.14387.

Costinot, A., Donaldson, D. (2020). Ricardo’s Theory of Comparative Advantage: Old Idea, New Evidence. American Economic Review: Papers & Proceedings 2012, 102(3): 453–458.http://dx.doi.org/10.1257/aer.102.3.453.

Diakité, A. S. (2016). Ebola en Guinée: un révélateur des forces et faiblesses. Alternatives humanitaires, (Inaugural), 57‑65.

Fernandes, N. (2020). Economic effects of Coronavirus outbreak (COVID-19) on the world economy. University of Navarra, IESE Business school, European corporate governance Institute.

Flahault, A. (2009). Gestion d’une crise sanitaire : l’exemple du chikungunya. Les Tribunes de la santé, (22), 53‑66.

Gbolo, Z.B., Ngbolua, K.N., Mpiana, P.T., Ndanga, B.A., Pangodi, A.J.M., Masengo, A.C., Mudogo, V. (2019). Evaluation of the Clinical Efficiency of an Antisickling Polyherbal Formula Drepanoalpha in a Sickle cell disease Patient in Gbado-Lite City (Democratic Republic of the Congo) by Quantum Magnetic Resonance Analyzer. Britain International of Exact Sciences (BIoEx) Journal, 1(1), 36-48.

Humman, I., Boer, B. (2002). IUCN-The world Conservation Union. Legal and Institutional Frameworks for Sustainable Soils. A Preliminary Report. 1-15.

Inkoto, L.C., Kayembe, K., Mpiana, P.T., Ngbolua, K.N. (2020). A review on the Phytochemistry and Pharmacological properties of Picralima nitida Durand and H. (Apocynaceae family): A potential antiCovid-19 medicinal plant species. Emer Life Sci Res, 6(1), 64-75. doi: https://doi.org/10.31783/elsr.2020.616475.

Kekulé, A. S. (2015). Learning from Ebola Virus: How to Prevent Future Epidemics. Viruses, 7(7), 3789‑3797. https://doi.org/10.3390/v7072797.

Kruk, M. E., Myers, M., Varpilah, S. T., & Dahn, B. T. (2015). What is a resilient health system? Lessons from Ebola. The Lancet, 385(9980), 1910‑1912. https://doi.org/10.1016/S0140-6736(15)60755-3.

Maltais, S., (2019). La gestion résiliente des crises sanitaires dans les États fragiles : étude de la crise d’Ebola en Guinée. Thèse de Doctorat en développement international, Université d’Ottawa: Canada.

Marie-Josée, D., Marjorie D.M., Muriel S., Sarah T. (2020): Intergenerational occupational justice: Ethically reflecting on climate crisis, Journal of Occupational Science, 1-15. DOI: 10.1080/14427591.2020.1776148.

Mbadiko, M.C., Inkoto, L.C., Gbolo, B.Z., Lengbiye, M.E., Kilembe, T.J., Matondo, A., Mwanangombo, T.D., Ngoyi, M.E., Bongo, N.G., Falanga, M.C., Tshibangu, D.S.T., Tshilanda, D.D., Ngbolua, K.N., Mpiana, P.T. (2020). A Mini Review on the Phytochemistry, Toxicology and Antiviral Activity of Some Medically Interesting Zingiberaceae Species. Journal of Complementary and Alternative Medical Research 9(4), 44-56. doi: http://doi.org/10.9734/jocamr/2020/v9i430150.

Ministère de l’Environnement, Conservation de la Nature et Tourisme, MECNT (2014). Cinquième rapport national sur la mise en œuvre de la Conservation sur la Diversité Biologique, République démocratique du Congo.

Mpiana, P.T., Ngbolua, K.N., Tshibangu, D.S.T., Kilembe, T.J., Gbolo, B.Z., Mwanangombo, T.D., Inkoto, L.C., Lengbiye, M.E., Mbadi M.C., Matondo, A., Bongo, N.G., Tshilanda, D.D. (2020a). Aloe vera (L.) Burm. F. as a Potential Anti-COVID-19 Plant: A Mini-review of Its Antiviral Activity. European Journal of Medicinal Plants 31(8): 86-93. Doi: http://doi.org/10.9734/ejmp/2020/v31i830261.

Mpiana, P.T., Ngbolua, K.N., Tshibangu, D.S.T., Kilembe, J.T., Gbolo, B.Z., Mwanangombo, D.T., Inkoto, C.L., Lengbiye, E.M., Mbadiko, C.M., Matondo, A., Bongo, G.N., Tshilanda, D.D. (2020b). Identification of potential inhibitors of SARS-CoV-2 main protease from Aloe vera compounds: a molecular docking study, Chemical Physics Letters, doi: https://doi.org/10.1016/j.cplett.2020.137751.

Ngbolua, K.N., Mbadiko, M.C., Matondo, A., Bongo, N.G., Inkoto, L.C., Gbolo, Z.B., Lengbiye, M.E., Kilembe, T.J., Mwanangombo, D.T., Ngoyi, E.M., Falanga, M.C., Tshibangu, D.S.T., Tshilanda, D.D., Mpiana, P.T. Review on Ethno-botany, Virucidal Activity, Phytochemistry and Toxicology of Solanum genus: Potential Bio-resources for the Therapeutic Management of Covid-19. European Journal of Nutrition and Food Safety (in press).

Ngbolua, K.N. (2020a). Ethnobotanique quantitative : Approches méthodologiques pour l’évaluation et la valorisation du savoir endogène en régions tropicales. Editions Universitaires Européennes, Riga: Latvia. ISBN: 978-613-9-53635-1.

Ngbolua, K.N., Kumbali, N.G., Mbembo-wa-Mbembo, B., Kohowe, P.S., Kogana, K.F., Bongo, N.G., Masengo, A.C., Djolu, D.R. (2020b). First Report on Three Cases of Monkey pox in Nord Ubangi Province (Democratic Republic of the Congo). Britain International of Exact Sciences (BIoEx) Journal, 2(1), 120-125.

Ngbolua, K.N., Ngemale, G.M., Masengo, A.C., Ndolete, G.J.P., Bongo, N.G., Ndanga, B.A., Tshibangu, D.S.T., Tshilanda, D.D. (2020c). Survey on the Sale of Megaphrynium Macrostachyum (Marantaceae) Leaves in Gbado-Lite City and Surroundings (Nord Ubangi Province, Democratic Republic of the Congo). Budapest International Research in Exact Sciences (BirEx) Journal, 2(2), 157-167.

Ngbolua, K.N. (2019a). Evaluation de l’activité anti-drépanocytaire et antipaludique de quelques taxons végétaux de la République démocratique du Congo et de Madagascar. Editions Universitaires Européennes, Riga : Latvia. ISBN : 978-613-8-46359-7.

Ngbolua, K.N., Zuangbo, I., Molongo M., Masengo, A.C., Djolu, D.R., Yabuda, H., Bongo, N.G., Gbolo, Z.B., Monde-te-Kazangba, G. (2019b). Effect of Agricultural Residues Based-Compost on the Yield of Amaranthus hybridus L. (Amaranthaceae) in Gbado-Lite City, Nord-Ubangi (Democratic Republic of the Congo). Budapest International Research in Exact Sciences (BirEx) Journal, 1(4), 53-61.

Ngbolua, K.N., Kumbali N.G., Mbembo-wa-Mbembo, B., Djolu D.R., Bongo, N.G., Falanga, M.C., Gbolo, Z.B., Masengo, A.C., Libwa, M.T.B. (2019c). Epidemio-therapeutic Survey on Malnourished Children Aged 0-5 Years Old in the Gbado-Lite Health Zone (Nord Ubangi Province, Democratic Republic of the Congo). Britain International of Exact Sciences (BIoEx) Journal, 1(1), 22-28.

Ngbolua, K.N., Zuangbo, I., Molongo, M., Masengo, A.C., Djolu, D.R., Yabuda, H., Bongo, N.G, Gbolo, Z.B., Monde, -te-K.G. (2019d). Effect of Agricultural Residues Based-Compost on the Yield of Amaranthus hybridus L. (Amaranthaceae) in Gbado-Lite City, Nord-Ubangi (Democratic Republic of the Congo). Budapest International Research in Exact Sciences (BirEx) Journal, 1(4), 53-61. doi: https://doi.org/10.33258/birex.v1i4.477.

Ngbolua, K.N., Rafatro, H., Rakotoarimanana, H., Urverg, R.S., Mudogo, V., Mpiana, P.T., Tshibangu, D.S.T. (2011a). Pharmacological screening of some traditionally-used antimalarial plants from the Democratic Republic of Congo compared to its ecological taxonomic equivalence in Madagascar. Int. J. Biol. Chem. Sci., 5(5), 1797-1804.

Ngbolua, K.N., Rakotoarimanana, H., Rafatro, H., Urverg, R.S., Mudogo, V., Mpiana, P.T., Tshibangu, D.S.T. (2011b). Comparative antimalarial and cytotoxic activities of two Vernonia species: V. amygdalina from the Democratic Republic of Congo and V. cinerea subsp vialis endemic to Madagascar. Int. J. Biol. Chem. Sci., 5(1), 345-353.

Ngunde-te-Ngunde, S., Lengbiye, M.E., Tshidibi, D.J., Kengo, V.F., Djolu, D.J., Masengo, A.C., Gbolo, Z.B., Iteku, B.J., Mpiana, P.T., Ngbolua, K.N. (2019). Antisickling and Antibacterial Activites of Anthocleista schweinfurthii Gilg. (Gentianaceae) from Nonhuman Primates Pharmacopoeia in Democratic Republic of the Congo. Budapest International Research in Exact Sciences, 1(3), 14-20.

OCDE. (2016). États de fragilité 2015. Consulté à l’adresse http://www.oecd-ilibrary.org/development/etats-de-fragilite-2015_9789264248878-fr.

Randrantoarimbola L., Rafalimanantsoa J., Ratiarimananjatovo N., Randriamanantena A.A., Bongo N., Ngbolua K.N., Robijaona B. (2020). Formulation of Moringa oleifera Lam. based Bio-fortified Food Supplement for Pregnant Women in Madagascar, Indian Ocean. Britain International of Exact Sciences (BIoEx) Journal, 2(2), 533-540.

Timothy, R., Emily, D.C., Victoria, B.C., Angela, R.S., Bianca, D.J., Yvonne, T., Talata, S.L., Neff, W. (2020). Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study. Article. 1-8. https://doi.org/10.1016/S2214-109X(20)30229-1.

Villalobos, C. (2020). SARS-CoV-2 infections in the World: An estimation of the infected population and a measure of how higher detection rates save lives. https://www.researchgate.net/publication/341550218.

Wafaa, M.E., M.D., M.P.H., M.P.A., Jessica, J., M.D. (2020). Africa in the Path of Covid-19. The New England Journal of Medicine.1-2.




DOI: https://doi.org/10.33258/birex.v2i3.1067

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