Trisomy 18 Case, with and without Cardiac Surgery

Herlina Dimiati, Cut Nanda Feby Ayulinda

Abstract


Trisomy 18, known as Edwards Syndrome, is the second-largest chromosomal disorder with a poor prognosis with the survival rate from 5 to 10% at one year of age. The most common factors underlying death are congenital heart defects, heart failure, and pulmonary hypertension. Cardiac surgery performed to patients with Trisomy 18 is associated with a reduction of mortality. This case report presents two cases of Trisomy 18, in which one of them underwent cardiac surgery.


Keywords


trisomy 18; cardiac surgery; mortality

Full Text:

PDF

References


Bawo D. D. S, Ayodele, A., Oyedeji, Solomon, P. B., Frankland, O., Briyai, Jasper, F. N., and Abowei. 2020. Assessment of the Larvicidal Efficacy of the Hexane-Leaf-Extracts of Selected Tropical Plant Species. Budapest International Research in Exact Sciences (BirEx) Journal (2): 136-140.

Boghossian NS, Hansen NI, Bell EF, Stoll BJ, Murray JC, Carey JC, Adams-Chapman I, Shankaran S, Walsh MC, Laptook AR, Faix RG. Mortality and morbidity of VLBW infants with trisomy 13 or trisomy 18. Pediatrics. 2014 Feb 1;133(2):226-35.

Bruns D. A, Martinez A. An analysis of cardiac defects and surgical interventions in 84 cases with full trisomy 18. American journal of medical genetics Part A. 2016 Feb;170(2):337-43.

Bruns D, Campbell E. Twenty‐two survivors over the age of 1 year with full trisomy 18: presenting and current medical conditions. American Journal of Medical Genetics Part A. 2014 Mar;164(3):610-9.

Cereda A, Carey JC. The trisomy 18 syndrome. Orphanet journal of rare diseases. 2012 Dec 1;7(1):81.

Costello JP, Weiderhold A, Louis C, Shaughnessy C, Peer SM, Zurakowski D, Jonas RA, Nath DS. A contemporary, single-institutional experience of surgical versus expectant management of congenital heart disease in trisomy 13 and 18 patients. Pediatric cardiology. 2015 Jun 1;36(5):987-92.

Halawa, B., Azwana, and Panggabean, E. L. 2019. Sensitivity of Larva Spodoptera litura Against the Density of Spores of Fungi Metarhizium anisopliae on the Onion Plant Red (Allium cepa) in the Laboratory. Budapest International Research in Exact Sciences (BirEx) Journal (1): 35-41.

Imataka G, Suzumura H, Arisaka O. Clinical features and survival in individuals with trisomy 18: A retrospective one-center study of 44 patients who received intensive care treatments. Molecular medicine reports. 2016 Mar 1;13(3):2457-66.

Kaneko Y, Kobayashi J, Yamamoto Y, Yoda H, Kanetaka Y, Nakajima Y, Endo D, Tsuchiya K, Sato H, Kawakami T. Intensive cardiac management in patients with trisomy 13 or trisomy 18. American journal of medical genetics Part A. 2008 Jun 1;146(11):1372- 80.

Kosiv KA, Gossett JM, Bai S, Collins RT. Congenital heart surgery on in-hospital mortality in trisomy 13 and 18. Pediatrics. 2017 Nov 1;140(5):e20170772.

Maeda J, Yamagishi H, Furutani Y, Kamisago M, Waragai T, Oana S, Kajino H, Matsuura H, Mori K, Matsuoka R, Nakanishi T. The impact of cardiac surgery in patients with trisomy 18 and trisomy 13 in Japan. American journal of medical genetics Part A. 2011 Nov;155(11):2641-6.

Mullin J, Wolfe J, Bluebond‐Langner M, Craig F. Experiences of children with trisomy 18 referred to pediatric palliative care services on two continents. American Journal of Medical Genetics Part A. 2019 Jun;179(6):903-7.

Muneuchi J, Yamamoto J, Takahashi Y, Watanabe M, Yuge T, Ohno T, Imoto Y, Sese A, Joo K. Outcomes of cardiac surgery in trisomy 18 patients. Cardiology in the Young. 2011 Apr;21(2):209-15.

Nakai Y, Asano M, Nomura N, Matsumae H, Mishima A. Effectiveness of cardiac surgery in patients with trisomy 18: a single-institutional experience. Cardiology in the Young. 2016 Oct;26(7):1391-6.

Syahrul, Mutiawati, E., Astini, N., Fajri, N., and Suherman. 2020. Clinical Characteristic Myasthenia Gravis among Indonesians. Budapest International Research in Exact Sciences (BirEx) Journal (2): 257-263.

Yamagishi H .Cardiovascular Surgery for Congenital Heart Disease Associated with Trisomy Gen Thorac Cardiovasc Surg 2010 May;58:217–219.




DOI: https://doi.org/10.33258/birex.v2i3.1163

Article Metrics

Abstract view : 37 times
PDF - 17 times

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.