Increased Productivity towards the Success of Nothopanax Scutellarium in Case Of Hepatoprotector and Nefroprotector

Sri Wahyuni Nasution

Abstract


This study aims to determine the concentration of bowl leaf extract (Nothopanax scutellarium) which is effective in protecting impaired liver and kidney function. Liver damage can cause metabolic disorders in the body, which will lead to homeostatic disorders. Acute renal failure is a clinical problem, occurring frequently and characterized by a relatively sudden decline in renal function. This research is qualitative experimental research using a male rat (Rattus norvegicus) which is healthy and has normal activity, with a bodyweight of 200 g. Male rats were adapted to be kept in cages for 7 days. Adaptation needed to be done to avoid the risk of stress in mice which could affect blood serum content. During the adaptation period, male rats are only given standard food and have not been given any treatment. At the end of the adaptation period, serum analysis was carried out in the five treatment groups. The results of the data obtained from this study were analyzed using the Oneway-Anova test.

Keywords


ethanol extract of mangkok leaves; increased productivity; kidney function

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References


Adiyati, P. N.(2011). Ragam Jenis Ektoparasit pada Hewan Coba Tikus Putih (Rattus norvegicus) Galur Sprague Dawley. Skripsi. Fakultas Kedokteran Hewan Institut Pertanian Bogor. Bogor.

Azis, A (2018). Pengaruh Jus Buah Durian Mentega ( Durio zibethinus Murr.) Terhadap Profil Farmakokinetik Parasetamol pada Kelinci Jantan. Jurnal Kesehatan.

Efendi, E., Fuad, A. P., Mudzakir, T., Kiky, M. A., Ain, Y., Insani, dan B. G. A (2016). Efek nefroprotektif ekstrak bawang kucai (allium tuberosum) terhadap kadar blood urea nitrogen (bun) dan kreatinin tikus wistar yang diinduksi doxorubicin. Nurseline Journal. Vol 1. No. 2: 203-211.

F. Paulsen dan J.Waschke. Sobotta, Atlas Anatomi Manusia Ed. 23. Jakarta Ganong, W.F., (2010). Pathophysiology of Disease: An Introduction to Clinical Medicine, 5th Ed.,diterjemahkan oleh Brahm, U., hal 493-500 , EGC, Jakarta.

Goodman, A., dan Gilman, H. (2014). Dasar Farmakologi Terapi Ed. 10 Vol. 2 Jakarta.EGC.

Harmita, Radji. (2010). Buku ajar Analisis Hayati. Jakarta. EGC.

Herman, H., Sitti, A., dan Triani, P. A. Efek hepatoprotektor ekstrak etanol rimpang dringo (Acorus calamus L.) terhadap peningkatan kadar SGPT tikus putih (Rattus norvegicus). As-Syifaa. Vol. 10(1): 92-98.

Hidayat, S., Napitupulu, R.M. (2015). Kitab Tumbuhan Obat. Jakarta: AgriFlo (Penebar Swadaya Grup). 265.

Irianto, K.( 2013). Anatomi dan Fisiologi Untuk Mahasiswa. Penerbit Alfabeta. Bandung.

Jozwiak-Bebenista, M. and Nowak, J. Z. (2014) ‘Paracetamol: Mechanism of action, applications and safety concern’, Acta Poloniae Pharmaceutica - Drug Research, 71(1). 11–23.

Kalender, Y., Yel, M., and Kalender, S. (2005). Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats. The effects of vitamin E and Ndruru, M. F., dan Edward, K. (2019). Uji efektivitas ekstrak daun benalu jeruk (Dendrophthoe glabrescens) sebagai nefroprotektor terhadap kerusakan ginjal yang di induksi dengan paracetamol pada tikus putih (Rattus novergicus). Jurnal Biosains. Vol. 5 No. 2. 45-52.

Maswita. (2020). The Role of Health Promotion on Smoke Free Area Implementation at Regional Work Unit Langsa City. ritain International of Exact Sciences (BIoEx) Journal.p. 298-303.

Sarpini, R. (2014). Anatomi dan Fisiologi Tubuh Manusia Untuk Paramedis.Bogor:Penerbit IN MEDIA.

Setiati S, Alwi I, Sudoyo AW, Stiyohadi B, Syam AF. Buku ajar ilmu penyakit dalam jilid I. VI. Jakarta: InternaPublishing; 2014.

Sherwood, lauralee (2014) Fisiologi Manusia. 8th edn. Jakarta: EGC Medical Publisher.

Snell, Richard S. (2014). Anatomi Klinis. Jakarta. EGC.




DOI: https://doi.org/10.33258/birci.v4i2.1861

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