Management of Covid-19 Vaccination for the Elderly

Deitje Adolfien Katuuk, Jeffry Sony Junus Lengkong, Viktory Nicodemus Joufree Rotty, Rinny Meilani Tinangon


Report of covid-19 Center for Disease Control (CDC) in16 March showed that 31% of the 4,226 confirmed COVID-19 cases were people aged ≥ 65 years. The susceptibility of elderly individuals to several diseases is due to decreased immunity. Therefore, COVID-19 vaccination is an important step to take. This article aims to determine the management of COVID-19 vaccination in the elderly. Based on the results of the analysis, it can be concluded that vaccination is a preventive strategy to increase immunity in the elderly. Although the immune response is greatly reduced due to the aging process, the right adjuvant formulation can increase the effectiveness of the vaccine. An understanding of the adjuvant mechanism to increase vaccine effectiveness is needed to develop a stronger vaccine response in elderly individuals.


vaccination management, covid-19, elderly

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Amanat, F., & Krammer, F. (2020). SARS-CoV-2 vaccines: status report. Immunity, 52(4), 583–589.

Azwar, M. K., Setiati, S., Rizka, A., Fitriana, I., Saldi, S. R. F., & Safitri, E. D. (2020). Clinical Profile of Elderly Patients with COVID-19 hospitalised in Indonesia’s National General Hospital. Acta Medica Indonesiana, 52(3), 199.

Bell, H. T., Granas, A. G., Enmarker, I., Omli, R., & Steinsbekk, A. (2017). Nurses’ and pharmacists’ learning experiences from participating in interprofessional medication reviews for elderly in primary health care-a qualitative study. BMC Family Practice, 18(1), 1–9.

Callaway, E. (2020). The race for coronavirus vaccines: a graphical guide. Nature, 580(7805), 576.

Chen, W. H., Kozlovsky, B. F., Effros, R. B., Grubeck-Loebenstein, B., Edelman, R., & Sztein, M. B. (2009). Vaccination in the elderly: an immunological perspective. Trends in Immunology, 30(7), 351–359.

Corsini, E., Vismara, L., Lucchi, L., Viviani, B., Govoni, S., Galli, C. L., Marinovich, M., & Racchi, M. (2006). High interleukin‐10 production is associated with low antibody response to influenza vaccination in the elderly. Journal of Leukocyte Biology, 80(2), 376–382.

COVID, G. P. (2020). 19. Peta Sebaran. Gugus Tugas Percepatan Penanganan COVID

Covid19. Go. Id.

Dey, A. B., Chatterjee, P., & Das, P. C. (2012). Immune status in the elderly. Medicine Update.

Fagundes, C. P., Gillie, B. L., Derry, H. M., Bennett, J. M., & Kiecolt-Glaser, J. K. (2012). Resilience and immune function in older adults. Annual Review of Gerontology and Geriatrics, 32(1), 29–47.

Giurgea, L. T., Han, A., & Memoli, M. J. (2020). Universal coronavirus vaccines: the time to start is now. Npj Vaccines, 5(1), 1–3.

Glaser, R., Sheridan, J., Malarkey, W. B., MacCallum, R. C., & Kiecolt-Glaser, J. K. (2000). Chronic stress modulates the immune response to a pneumococcal pneumonia vaccine. Psychosomatic Medicine, 62(6), 804–807.

Greenwood, B. (2014). The contribution of vaccination to global health: past, present and future. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1645), 20130433.

Güçyetmez, et al. (2020). Implications behind the Covid 19: A Profound Structural Change Out Of Catastrophy?. Britain International of Humanities and Social Sciences (BIoHS) Journal, 690-697.

Hoffmann, M., Kleine-Weber, H., Krüger, N., Mueller, M. A., Drosten, C., & Pöhlmann, S. (2020). The novel coronavirus 2019 (2019-nCoV) uses the SARS- coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells. BioRxiv.

Indonesia, P. R. (2021). Petunjuk Teknis Pelaksanaan Vaksinasi Dalam Rangka Penanggulangan Pandemi Corona Virus Disease 2019 (Covid-19). Keputusan Direktur Jenderal Pencegahan Dan Pengendalian Penyakit Nomor Hk.02.02/4/ 4’13/2021.

Kaslow, D. C. (2020). Certainty of success: three critical parameters in coronavirus vaccine development. Npj Vaccines, 5(1), 1–7.

Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003). Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proceedings of the National Academy of Sciences, 100(15), 9090–9095.

Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, K. S. M., Lau,

E. H. Y., & Wong, J. Y. (2020). Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia. New England Journal of Medicine.

Li, T., Zhang, Y., Gong, C., Wang, J., Liu, B., Shi, L., & Duan, J. (2020). Prevalence of malnutrition and analysis of related factors in elderly patients with COVID-19 in Wuhan, China. European Journal of Clinical Nutrition, 74(6), 871–875.

Liu, K., Chen, Y., Lin, R., & Han, K. (2020). Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients. Journal of Infection, 80(6), e14–e18.

Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Song, H., Huang, B., & Zhu, N. (2020). Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet, 395(10224), 565–574.

Mergenthal, K., Beyer, M., Gerlach, F. M., & Guethlin, C. (2016). Sharing responsibilities within the general practice team–a cross-sectional study of task delegation in Germany. PloS One, 11(6), e0157248.

Morens, D. M., & Taubenberger, J. K. (2019). Making universal influenza vaccines: lessons from the 1918 pandemic. The Journal of Infectious Diseases.

Ningrum, et al. (2020). The Potential of Poverty in the City of Palangka Raya: Study SMIs Affected Pandemic Covid 19. Budapest International Research and Critics Institute-Journal (BIRCI-Journal), 1626-1634.

Onder, G., Rezza, G., & Brusaferro, S. (2020). Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. Jama, 323(18), 1775–1776.

Ongrádi, J., & Kövesdi, V. (2010). Factors that may impact on immunosenescence: an appraisal. Immunity & Ageing, 7(1), 1–14.

Paterson, P., Meurice, F., Stanberry, L. R., Glismann, S., Rosenthal, S. L., & Larson, H.

J. (2016). Vaccine hesitancy and healthcare providers. Vaccine, 34(52), 6700– 6706.

Perrotta, F., Corbi, G., Mazzeo, G., Boccia, M., Aronne, L., D’Agnano, V., Komici, K., Mazzarella, G., Parrella, R., & Bianco, A. (2020). COVID-19 and the elderly: insights into pathogenesis and clinical decision-making. Aging Clinical and Experimental Research, 1–10.

PPADI. (2021). Rekomendasi PAPDI tentang Pemberian Vaksinasi covlD-19 (coronavac) pada Pasien dengan Penyakit Penfdrta/ Komorbid (Revisi 9 Februari 2021). PENGURUS BESAR PERHIMPUNAN DOKTER SPESIALIS PENYAKIT DALAM INDONESIA.


COVID-19 (E. Burhan, A. D. Susanto, F. Isbaniah, S. A. Nasution, Eka, Ginanjar,

C. W. Pitoyo, A. Susilo, I. Firdaus, A. Santoso, D. A. Juzar, S. K. Arif, N. G. . L. Wulung, & F. Muc (eds.); 3rd ed.).

RI., K. K. (2020). Pedoman Pencegahan Pengendalia Coronavirus Disease (COVID- 19) (S. K. dr. Listiana Aziza, S. Adistikah Aqmarina, & S. Maulidiah Ihsan (eds.); 13 Juli 20).

Schuchat, A. (2011). Human vaccines and their importance to public health. Procedia in Vaccinology, 5, 120–126.

Shang, W., Yang, Y., Rao, Y., & Rao, X. (2020). The outbreak of SARS-CoV-2 pneumonia calls for viral vaccines. Npj Vaccines, 5(1), 1–3.

Sihombing, E. H., Nasib. (2020). The Decision of Choosing Course in the Era of Covid 19 through the Telemarketing Program, Personal Selling and College Image. Budapest International Research and Critics Institute-Journal (BIRCI-Journal), 2843-2850.

Tay, M. Z., Poh, C. M., Rénia, L., MacAry, P. A., & Ng, L. F. P. (2020). The trinity of COVID-19: immunity, inflammation and intervention. Nature Reviews Immunology, 20(6), 363–374.

Team, C. D. C. C.-19 R., Team, C. D. C. C.-19 R., Team, C. D. C. C.-19 R., Bialek, S.,

Boundy, E., Bowen, V., Chow, N., Cohn, A., Dowling, N., & Ellington, S. (2020). Severe outcomes among patients with coronavirus disease 2019 (COVID-19)— United States, February 12–March 16, 2020. Morbidity and Mortality Weekly Report, 69(12), 343–346.

Weltermann, B. M., Markic, M., Thielmann, A., Gesenhues, S., & Hermann, M. (2014). Vaccination management and vaccination errors: a representative online-survey among primary care physicians. PloS One, 9(8), e105119.

Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., & Huang, C.-L. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270–273.


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