Effectiveness of Gelatin Tannate among Children with Acute Diarrhea: A Systematic Review and Meta-Analysis

Farahdina Farahdina, Claudia Herda, Siti Habibah Zein, Vatine Adila


Gelatin tannate has been proposed as a theoretically effective treatment for treating acute diarrhea in children. Vegetable tannins have attracted a lot of attention in recent years because of their multifunctional properties, such as beneficial to human health and recently, an antidiarrhea effect of gelatin tannate has been reported. However, inconsistency across the studies was reported. This study aims to perform a meta-analysis concerning the efficacy of gelatin tannate administration for treating acute diarrhea in children Published papers from PubMed, Embase, Cochrane, and Google Scholar were collected, and they were analyzed using a fixed or random-effect model. A total of three relevant papers were included in our analysis. Our pooled analysis found that gelatin tannate administration, compared to control, was associated with reduced stool frequency (mean diff: 0.79 [95%CI: 0.44-1.15], p = 0.000). However, duration of diarrhea (mean diff: 10.87 [95%CI: -7.71-29.46], p = 0.25), weight gain (mean diff: 47.22 [95%CI: -22.81-117.24], p = 0.19), vomiting (OR: 0.57 [95%CI: 0.23-1.41], p = 0.22), and side effects (OR: 1.39 [0.42-4.63], p = 0.59) were not affected significantly between treatment and control groups. Gelatin tannate administration provides the efficacy to reduce stool frequency in children with acute diarrhea.


Gelatin tannate; acute diarrhea; adjuvant therapy

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Abedi D, Feizizadeh S, Akbari V, Jafarian- Dehkordi A. In vitro anti-bacterial and anti- adherence effects of Lactobacillus delbrueckii subsp bulgaricus on Escherichia coli. Res Pharm Alexander KA, Blackburn JK. Overcoming barriers in evaluating outbreaks of diarrheal disease in resource poor settings: assessment of recurrent outbreaks in Chobe District, Botswana. BMC Public Health 2013; 13: 775. doi: 10.1186/1471-2458-13-775

Adinda, D. et al. (2019). Relationship of Teacher’s Role and Nutrient Intake with Obesity in Elementary School Student at Medan Maimun Sub-district, Indonesia. Budapest International Research and Critics Institute-Journal (BIRCI-Journal). P. 537-544

Aloi M, Mennini M. Efficacy of gelatin tannate for acute diarrhea in children: a systematic review and meta-analysis. Journal of Comparative Effectiveness Research. 2019;8(2):91-102.

Ashok PK, Upadhyaya K. Tannins are astringent. J Pharmacognosy Phytochem 2012;1:45-50.

Bulled N, Singer M, Dillingham R. The syndemics of childhood diarrhoea: a biosocial perspective on efforts to combat global inequities in diarrhoea-related morbidity and mortality. Glob

Bustreo F, Okwo-Bele JM, Kamara L. World Health Organization perspectives on the contribution of the Global Alliance for Vaccines and Immunization on reducing child mortality. Arch Dis Child 2015; 100(Suppl. 1): S34: S37. doi: 10.1136/archdischild-2013-305693 Sci. 2013;8(4):260–268.

Cheikhyoussef A, Pogori N, Chen W, Zhang H. Antimicrobial proteinaceous compounds obtained from bifidobacteria: from pro- duction to their application. Int J Food Microbiol. 2008;125(3):215–222.

Çağan E, Ceylan S, Mengi Ş, Çağan H. Evaluation of Gelatin Tannate Against Symptoms of Acute Diarrhea in Pediatric Patients. Medical Science Monitor. 2017;23:2029-2034. doi: 10.12659/MSM.903158

Chung KT, Stevens SE Jr, Lin WF, Wei CI. Growth inhibition of selected foodborne bacteria by tannic acid, propyl gallate and related compounds. Lett Appl Microbiol 1993; 17:29-32.

De Servi B, Moreira da Silva R, Meloni M. New insight into the mechanism of action of gelatine tannate for acute diarrhoea. Pat 2: antibacterial activity.

Esteban Carretero J, Durban Reguera F, Lopez-Argueta Alvarez S, et al. A comparative analysis of response to ORS (oral rehydration solution) vs ORS? gelatin tannate in two cohorts of pediatric patients with acute diarrhea. Rev Esp Enferm Dig. 2009;101:41–8.

Farthing M, Salam MA, Lindberg G, Dite P, Khalif I, Salazar-Lindo E, et al.; WGO. Acute diarrhea in adults and children: a global perspective. J Clin Gastroenterol. 2013; 47(1):12-20

Farthing M. Novel targets for the pharmacotherapy of diarrhoea: a view for the millennium. J Gastroenterol Hepatol. 2000; 15:38–45.

Fiedoruk K, Daniluk T, Rozkiewicz D, et al. Conventional and molecular methods in the diagnosis of community-acquired diarrhoea in children under 5 years of age from the north-eastern region of Poland. Int J Infect Dis 2015; 37: 145–151. doi: 10.1016/j.ijid.2015.06.028 Public Health 2014; 9: 841–853.

Florez I, Sierra J, Niño-Serna L. Gelatin tannate for acute diarrhoea and gastroenteritis in children: a systematic review and meta-analysis. Archives of Disease in Childhood. 2019; archdischild-2018-316385.

Freli V, Moreira da Silva R, Pescio P. New insights into the mechanism of action of gelatine tannate for acute diarrhoea. Part 1: film-forming effect. Available at: http://www.tasectan.ie/wp-content/

Global Burden of Disease 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2015; 385: 117–171. doi: 10.1016/S0140-6736(14)61682-2

Global Burden of Diarrhoeal Diseases Collaborators. Estimates of global, regional, national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Infect Dis 2017; 17: 909–948. doi: 10.1016/S1473-3099(17)30276-1

Guandalini S, Kahn SA. Acute diarrhea. In: Kleinman RE, Sanderson IR, Goulet O, Sherman PM, Mieli-Vergani G, Shneider B, editors. Walker’s Pediatric Gastrointestinal Disease. 5th ed. Hamilton: BC Decker Inc; 2008. p.253-64

Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr. 2014; 59(1):132-52.

Guarino A, Lo Vecchio A, Canani RB. Probiotics as prevention and treatment for diarrhea. Curr Opin Gastroenterol. 2009;25(1):18–23.

Kara SS, Volkan B, Erten İ. The therapeutic effect of gelatin tannate in acute diarrhea in children. Turk J Pediatr. 2017;59(5):531-536.

Karimi A, Mansour Ghanaie R. Management of Acute Infectious Gastroenteritis in Children. Journal of Comprehensive Pediatrics. 2014;5(1).

Kołodziej M, Bebenek D, Konarska Z, Szajewska H. Gelatine tannate in the management of acute gastroenteritis in children: a randomised controlled trial. BMJ open. 2018;8(5).

Koletzko S, Osterrieder S. Acute infectious diarrhea in children. Dtsch Arztebl Int. 2009; 106(33):539-47. doi: 10.3238/arztebl.2009.0539

Kotloff KL, Nataro P, Blackwelde WC, et al. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study. Lancet 2013; 382: 209–222. doi: 10.1016/S0140-6736(13)60844-2

L. Lopetuso, C. Graziani, A. Guarino, A. Lamborghini, S. Masi, V. Stanghellini. Gelatin tannate and tyndallized probiotics: a novel approach for treatment of diarrhea. Eur. Rev. Med. Pharmacol. Sci. 2017; 21: 873-883.

Liu C, Zheng Y, Xu W, Wang H, Lin N. Rhubarb tannins extract inhibits the expression of aquaporins 2 and 3 in magnesium sulphate-induced diarrhoea model. BioMed research international. 2014;2014.

Matsuzaki T, Chin J. Modulating immune responses with probiotic bacteria. Immu- nol Cell Biol. 2000;78(1):67–73.

Mennini M, Tolone C, Frassanito A, Midulla F, Cucchiara S, Aloi M. Gelatin Tannate for Acute Childhood Gastroenteritis: A Randomized, Single-Blind Controlled Trial. Paediatr Drugs. 2017 Apr;19(2):131-137. DOI: 10.1007/s40272-016-0207-z

Oi H, Matsuura D, Miyake M, et al. Identification in traditional herbal medications and confirmation by synthesis of factors that inhibit cholera toxin-induced fluid accumulation. Proc Natl Acad Sci 2002; 99: 3042-3046.

Sawin-Johnson KN, Packer CD. Norovirus-induced Gastroparesis. Cureus. 2019 Dec;11(12).

Serban E, Manolache M. Gelatin tannate versus other antidiarrheal medication in children with acute gastroenteritis: a retrospective, observational study. Journal of Comparative Effectiveness Research. 2019;8(3):187-194.

Scalbert A. Antimicrobial properties of tannins. Phytochemistry 1991; 30:3875-3883.

Scaldaferri F, Lopetuso LR, Petito V, et al. Gelatin tannate ameliorates acute colitis in mice by reinforcing mucus layer and modulating gut microbiota composition: emerging role for ‘gut barrier protectors’ in IBD? United European Gastroenterol J. 2014; 2:113–22

Yoshida T, Amakura Y, Yoshimura M. Structural features and biological properties of ellagitannins in some plant families of the order myrtales. Int J Mol Sci. 2010;11:79–106.

DOI: https://doi.org/10.33258/birci.v4i3.2230

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