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The Effects of Gavage Extract of Papaver Rhoeas L on Blood Pressure of MIA Induced Osteoarthritis and Its Interaction with Nitrergic System in male Rat
Abstract
Hypertension is one of the most common and most prevalent diseases in the world today. Chronic inflammation is one of the risk factors for cardiovascular disease (CVD). Since synovial inflammation plays a role in the initial stages of osteoarthritis (OA), therefore, the side effects of OA are the incidence of CVD. One of the most appropriate methods for treating this disease is the use of medicinal herbs that have a blood pressure modifying effect Due to OA as Papaver rhoeas. The present research shows The Effects of Extract of Papaver rhoeas on Blood Pressure of rats with OA and Its Interaction with nitrergic System. OA model in 35 male rats was created by injection of monosodium iodoacetate (MIA) into the right knee joint and then were gavaged with extract of Papaver rhoeas for 30 days. On day 30, the veins and arteries of the animal were then cannulated for injection and measurement of blood pressure, respectively. Blood pressure parameters (systolic, diastolic, mean arterial pressure) were recorded in groups before and after L-NAME injection. The results were analyzed using SPSS software. Systolic, diastolic, and mean arterial pressure in response to extract of Papaver rhoeas was reduced compared to control(OA), as well as Significant decrease in systolic and diastolic pressure and mean arterial pressure and increased heart beat rate in the presence of extract and LNAME as compared with control group. (P <0/05) .We found that the aqueous extract of Papaver rhoeas has a decreasing effect on blood pressure in rats with OA. This effect may be due to inhibition of the nitrergic system.
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Agnieszka Pajak, Magdalena Kostrzewa, Natalia Malek, Michal Korostynski, Katarzyna Starowicz.(2017). Expression of matrix metalloproteinases and components of the endocannabinoid system in the knee joint are associated with biphasic pain progression in a rat model of osteoarthritis J Pain Res.
Azis1. R , Ciptadi.G, Suyadi.. (2020). Genetic Parameters of Birth Weight, Litter Size in Crossbreeding of Boer and Indonesian Goat. Budapest International Research in Exact Sciences (BirEx) Journal Volume 2, No 3, Page: 273-279. www.bircu-journal.com/index.php/birex
Farrokhi E, Shafei M N, Khajavirad A, Hosseini M, Bideskan A R E. (2017). Role of the Nitrergic System of the Cuneiform Nucleus in Cardiovascular Responses in Urethane-Anesthetized Male Rats. Iranian Journal of Medical Sciences.
Gargiulo G, Capodanno D, Longo G, Capranzano P,Tamburino C.(2014). Updates on NSAIDs in patients with and without coronary artery disease: pitfalls, interactions and cardiovascular outcomes. Expert review of cardiovascular therapy.
Guzman R E, Evans M G, Bove S, Morenko B, Kilgore, K.(2003). Mono-iodoacetate-induced histologic changes in subchondral bone and articular cartilage of rat femorotibial joints: an animal model of osteoarthritis. Toxicologic Pathology : 619-624.
Hosseini S E, Hamzavi S, Aghababa H.(2015). The effects of alcoholic extract of red poppy (Papaver rhoeas) on anxiety induced by elevated plus maze and the plasma corticosterone levels in adult male wistar rats .
Huston J M, Tracey K J. (2011). The pulse of inflammation: heart rate variability, the cholinergic anti‐inflammatory pathway and implications for therapy. Journal of internal medicine.
Jennings A, Welch A A, Fairweather-Tait S J, Kay C, Minihane A M, Chowienczyk, P, et al. (2012). Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women. The American journal of clinical nutrition .
Karimian P, Kavoosi G, Amirghofran. Z.(2013). Anti-inflammatory effect of Mentha longifolia in lipopolysaccharide-stimulated macrophages: reduction of nitric oxide production through inhibition of inducible nitric oxide synthase , J Immunotoxicol :393
Kent K, Charlton K E, Jenner A, & Roodenrys S. (2016). Acute reduction in blood pressure following consumption of anthocyanin-rich cherry juice may be dose-interval dependant: a pilot cross-over study. International journal of food sciences and nutrition: 47-52.
Marcocci L., Maguire J J, Droylefaix M T, and Packer L. (1994). Nitric oxide scavengiing properties of Ginkgo biloba extract EGB 761. Bioechm. Biophys. Res. Commun: 748-75.
Osanloo N, Najafi-Abedi A, Jafari F, Javid F, Pirpiran M, Jafari M R M, et al. (2016). Papaver Rhoeas L. Hydroalcoholic Extract Exacerbates Forced Swimming Test-Induced Depression in Mice. Basic and clinical neuroscience.
Perrinjaquet-Moccetti T, Busjahn A, Schmidlin C, Schmidt A, Bradl B, aydoganfood.(2008). "Supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins." Phytotherapy Research .
Qiang Xu,A,B,C,D,E,F Zuo-fu Zhang,B,E and Wei-xue SunA.(2017). Effect of Naringin on Monosodium Iodoacetate-Induced Osteoarthritis Pain in Rats. Med Sci Monit. : 3746–3751.
Reddy M K, Schultz H D, Zheng H, Patel K P. (2007). Altered nitric oxide mechanism within the paraventricular nucleus contributes to the augmented carotid body chemoreflex in heart failure. American Journal of Physiology-Heart and Circulatory Physiology : 149-157
Sahraei H, Faghih‐Monzavi Z, Fatemi S M, Pashaei‐Rad S, Salimi S H, et al.(2006). Effects of Papaver rhoeas extract on the acquisition and expression of morphine induced behavioral sensitization in mice. Phytotherapy Research.
Wang H, Bai J, He B, Hu X, & Liu D. (2016). Osteoarthritis and the risk of cardiovascular disease: a meta-analysis of observational studies. Scientific reports.
Wang Z, Martorell, B C, Wälchli T, Vogel O, Fischer J, Born W, Vogel J.(2015). Calcitonin gene-related peptide (CGRP) receptors are important to maintain cerebrovascular reactivity in chronic hypertension. PloS one 123.
Zigta, Binyam. ( 2019). Thermal Radiation, Chemical Reaction and Viscous Dissipation Effects on Unsteady MHD Flow of Viscoelastic Fluid Embedded in a Porous Medium. Budapest International Research in Exact Sciences (BirEx) Journal Volume 1, No 3, July 2019, Page: 35-57 www.bircu-journal.com/index.php/birex
DOI: https://doi.org/10.33258/birex.v2i4.1260
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