Effectiveness of Turmeric Ethanol Extract (Curcuma Longa) in Accelerating Wound Healing After in Wistar Rats

Zhou Guoqing, Florenly Florenly, Liena Liena, Johannes Bastira

Abstract


RISKESDAS results in 2018 showed the DMFT (Decay, Missing and Filled Teeth) index of Indonesian people nationally 2.5% in 2013, rising to 57.6% in 2018. The main cells involved in the wound healing process are fibroblasts. Fibroblasts are stem cells that play a role in forming and putting fibers in the matrix, especially collagen fibers. Turmeric (Curcuma longa) has several pharmacological properties, including anti-inflammatory, anticancer, antioxidant, antiulcus, and antibacterial actions. The content of flavonoids in Curcuma longa, as an immunostimulating substance, then the production of growth hormones such as EGF, TGFα, PDGF, VEGF, FGF, and TGFβ will also increase, so that wound healing can be accelerated. This study was conducted to find out the effectiveness of turmeric ethanol extract (Curcuma Longa) in accelerating wound healing after tooth extraction. This study used 32 male Wistar rats divided into 2 groups, namely the treatment group given turmeric extract (Curcuma Longa) 45% and the treatment group given turmeric (Curcuma Longa) 90%. The wound healing process was assessed by observing fibroblast tissue on the 5th day after the extraction of Wistar mouse teeth. The results of the Chi-Square Test statistical analysis showed a significant difference in the number of fibroblasts in the wound healing process in Wistar rats after tooth extraction between the treatment group given turmeric extract (Curcuma Longa) 45% and the treatment group given Turmeric extract (Curcuma Longa) 90% after the 5th day with p-value (0.032)<0.05). Turmeric extract (Curcuma longa) is 45% and 90% effective in speeding up the healing time of post-extraction wounds of Wistar mouse teeth. Turmeric extract (Curcuma longa) is 90% more effective than turmeric extract (Curcuma longa) 45% in speeding up wound healing time after extraction of rat teeth Wistar because of the flavonoid content in turmeric extract (Curcuma longa) 90% which helps accelerate wound healing higher than turmeric extract (Curcuma longa) 45%.


Keywords


tooth extraction; turmeric (Curcuma Longa); wound healing; fibroblasts

Full Text:

PDF

References


Abdul-Aziz, Karolin Kamel. 2011. “Comparative Evaluation of the Anti-Ulcer Activity of Curcumin and Omeprazole during the Acute Phase of Gastric Ulcer—Efficacy of Curcumin in Gastric Ulcer Prevention against Omeprazole.” Food and Nutrition Sciences 02(06):628–40.

Akbik, Dania, Maliheh Ghadiri, Wojciech Chrzanowski, and Ramin Rohanizadeh. 2014. “Curcumin as a Wound Healing Agent.” Life Sciences 116(1):1–7.

Amanah, Siti, and Dwi Sadono. 2017. “Tingkat Kedinamisan Kelompok Wanita Tani Dalam Mendukung Keberlanjutan Usaha Tanaman Obat Keluarga Di Kabupaten Bogor, Jawa Barat.” Jurnal Penyuluhan 13(2):181–93.

Ayati, Zahra, Mahin Ramezani, Mohammad Sadegh Amiri, Ali Tafazoli Moghadam, Hoda Rahimi, Aref Abdollahzade, Amirhossein Sahebkar, and Seyed Ahmad Emami. 2019. “Ethnobotany, Phytochemistry and Traditional Uses of Curcuma Spp. and Pharmacological Profile of Two Important Species (C. Longa and C. Zedoaria): A Review.” Current Pharmaceutical Design 25(8):871–935.

Bakar, A. 2014. Kedokteran Gigi Klinis. Yogyakarta: Quantum Sinergis Media.

Budiman, Iwan, and Derrick. 2013. “Aktivitas Penyembuhan Luka Rimpang Kunyit (Curcuma Longa Linn.) Terhadap Luka Insisi Pada Mencit Swiss-Webster Jantan Dewasa.” Aktivitas Penyembuhan Luka Rimpang Kunyit (Curcuma Longa Linn.) Terhadap Luka Insisi Pada Mencit Swiss-Webster Jantan Dewasa (Fakultas Kedokteran, Universitas Kristen Maranatha).

Budiman, Iwan, Jalan Prof, Drg Suria, Sumantri Mph, and No Bandung. 2015. “Rimpang Kunyit ( Curcuma Longa Linn .) terhadap Luka Insisi pada Mencit Swiss-Webster Jantan Dewasa Turmeric ( Curcuma Longa Linn .) Wound Healing Activity towards Incision on Wound Model of Adult Swiss-Webster Male Mice 1 Fakultas Kedokteran , Universita.” Perpustakaan Maranatha Thesis.

Chandra HM. 2014. Buku Petunjuk Praktis Pencabutan Gigi (1st Ed). Makassar: Sadgung Seto.

Fitriani, Diah. 2014. “Pengaruh Ekstrak Kunyit Terhadap Peningkatan Jumlah Makrofag Pada Soket Pasca Pencabutan Gigi Cavia Cobaya.” 1–4.

Junquiera, et. a. 2007. Histologi Dasar Teks Dan Atlas. Alih Bahas. Jakarta: EGC.

Kementerian Kesehatan Republik Indonesia. 2018. “Laporan Nasional Riset Kesehatan Dasar.” Kementrian Kesehatan RI 1–582.

Kocaadam, Betül, and Nevin Şanlier. 2017. “Curcumin, an Active Component of Turmeric (Curcuma Longa), and Its Effects on Health.” Critical Reviews in Food Science and Nutrition 57(13):2889–95.

Lande, Randy, Billy J. Kepel, and Krista V. Siagian. 2015. “Gambaran Faktor Risiko Dan Komplikasi Pencabutan Gigi Di Rsgm Pspdg-Fk Unsrat.” E-GIGI 3(2).

Lone, Parveen Akhter, Syed wakeel Ahmed, Vivek Prasad, and Bashir Ahmed. 2018. “Role of Turmeric in Management of Alveolar Osteitis (Dry Socket): A Randomised Clinical Study.” Journal of Oral Biology and Craniofacial Research 8(1):44–47.

Manarin, Gabriel, Daniela Anderson, Jorgete Maria e. Silva, Juliana da Silva Coppede, Persio Roxo-Junior, Ana Maria Soares Pereira, and Fabio Carmona. 2019. “Curcuma Longa L. Ameliorates Asthma Control in Children and Adolescents: A Randomized, Double-Blind, Controlled Trial.” Journal of Ethnopharmacology 238:111882.

Masir, Oky, Menkher Manjas, Andani Eka Putra, and Salmiah Agus. 2012. “Pengaruh Cairan Cultur Filtrate Fibroblast (CFF) Terhadap Penyembuhan Luka; Penelitian Eksperimental Pada Rattus Norvegicus Galur Wistar.” Jurnal Kesehatan Andalas 1(3):112–17.

Muthia Milasari, et al. 2019. “Pengaruh Pemberian Salep Ekstrak Kunyit Kuning (Curcuma Longa Linn) terhadap Penyembuhan Luka Sayat pada Tikus Putih (Rattus Norvegicus).” Jurnal Ilmiah Ibnu Sina 4(1):1–5.

Pedersen, G. .. 2012. Buku Ajar Praktis Bedah Mulut (Terj.). Jakarta: Buku Kedokteran EGC.

Rizka, Adi, Vicky S. Budipramana, and Dyah Fauziah. 2013. “Kepadatan Kolagen Tipe 1 Pada Luka Operasi Tikus Wistar Yang Mengalami Anemia Karena Perdarahan Akut.” Media Journal of Emergency 2(1):1.

Roihatul Mutiah. 2015. “Evidence Based Kurkumin dari Tanaman Kunyit (Curcuma Longa) sebagai Terapi Kanker pada Pengobatan Modern.” Jurnal Farma Sains 1(1):28–41.

Setiadi, Adi, Nurul Khumaida, and Dan Sintho Wahyuning Ardie. 2017. “Keragaman Beberapa Aksesi Temu Hitam (Curcuma Aeruginosa Roxb.) Berdasarkan Karakter Morfologi.” Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) 45(1):71–78.

Siagian, Krista V. 2016. “Kehilangan Sebagian Gigi Pada Rongga Mulut.” E-CliniC 4(1).

Sjamsuhidajat, R & Jong, W. .. 2010. Buku Ajar Ilmu Bedah, Ed.3. Jakarta: EGC.

Sorongan, Ryan Stefanus, and Krista V Siagian. 2015. “Efektivitas Perasan Daun Pepaya Terhadap Aktivitas Fibroblas Pasca Pencabutan Gigi Pada Tikus Wistar Jantan.” Pharmacon 4(4):52–57.

Winarsih, Wiwin, Ietje Wientarsih, and Lina Noviyanti Sutardi. 2012. “Aktivitas Salep Ekstrak Rimpang Kunyit Dalam Proses Persembuhan Luka Pada Mencit Yang Diinduksi Diabetes.” Jurnal Veteriner 13(3):242–50.

Yunesa, Cempaka Welen, Fakultas Kedokteran Gigi, and Universitas Sumatera Utara. 2019. “Pengaruh Pemberian Gel Hesperidin Universitas Sumatera Utara.”




DOI: https://doi.org/10.33258/birex.v3i4.2975

Article Metrics

Abstract view : 4 times
PDF - 1 times

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
 

 

Statcounter for Budapest International Research in Exact Sciences (BirEx Journal)