Analysis of Grade II Burns Healing from Andaliman Fruit Ethanol Extract Ointment (Zanthoxylum Acanthopodium Dc.) in Wistar Rats (Rattus Norvegicus)

Li Sha, Florenly Florenly, Johannes Bastira Ginting, Fioni Fioni

Abstract


The prevalence of injuries has increased every year, from riskesdas results data in 2013 reported that burns are the sixth cause of accidental injuries with a prevalence of 0.7 percent of the Indonesian population. Andaliman fruit extract with various phytochemicals has active physiological activity as a potential antioxidant and antimicrobial. The study aims to explore the wound healing effects of andaliman fruit ethanol extract. This study was an experimental study using 20 rats divided into 4 groups (Control, Standard, Essential Oil 10%, and Essential Oil 15%). Wound healing parameters are assessed through wound contraction and epithelial period. Samples of andaliman fruit used in this study were obtained from one of the traditional markets in the city of Medan. Essential oils are obtained from the hydrodistillation process. The results of the study showed significant differences in the epithelial period of the standard group, 10% and 15% in the control group. However, in the andaliman ointment group and the standard group, there was no difference in the epithelial period. This is evident from the value P < 0.05 (Value P = 0.029). The conclusion of the healing effects of burns possessed by andaliman ointment both 10% and 15% and nebacetin ointment as standard shows a significant difference. Where the wound contraction rate of your ointment is 15% better than nebacetin ointment as standard. But in both andaliman ointments, both 10% and 15% and nebacetin ointment as standard did not show significant differences in the parameters of the epithelial period.


Keywords


andaliman; essential oils; burns

Full Text:

PDF

References


Agussalim Bukhar. (2018). Departemen Gizi Klinik Fakultas Kedokteran Universitas Hasanuddin Makassar Email : 1, 80–90.

Asbur, Y., & Khairunnisyah, K. (2018). Pemanfatan andaliman (Zanthoxylum acanthopodium DC) sebagai tanaman penghasil minyak atsiri. Kultivasi, 17(1), 537–543. https://doi.org/10.24198/kultivasi.v17i1.15668

Batubara, M. S., Sabri, E., & Tanjung, M. (2018). Hasil Kandungan Kimia Ekstrak Etanol Daun Andaliman (Zanthoxylum Acanthopodium Dc.). EKSAKTA: Jurnal Penelitian Dan Pembelajaran MIPA, 2(1), 24–31.

Budiyanto, M. A. K. (n.d.). Efek ekstrak lidah buaya (.

Dinas Kesehatan Republik Indonesia. (2013). Riset Kesehatan Dasar. Diabetes Mellitus, 87–90. https://doi.org/1 Desember 2013

Ergina, Nuryanti, S., & Purtisari, I. D. (2014). Uji Kualitatif Senyawa Metabolit Sekunder Pada Daun Palado (Agave angustifolia) Yang Diekstraksi Dengan Pelarut Air Dan Etanol Qualitative Test of Secondary Metabolites Compounds in Palado Leaves (Agave). J. Akad. Kim, 3(3), 165–172.

Febiati, F. (2016). Uji efektivitas sediaan gel getah jarak cina ( (Issue September).

Hakim, A. M. (2020). Efektifitas Aloe vera terhadap Luka Bakar. Jurnal Ilmiah Kedokteran Wijaya Kusuma, 9(2), 245. https://doi.org/10.30742/jikw.v9i2.800

Hariani. (2016). Pengaruh Pemberian Etanol 96% Tumbuhan Paku Nephrolephis falcata (Cav.). C.Chr Terhadap Penyembuhan Luka Bakar Derajat Dua Pada Tikus Putih (Rattus norvegicus) Jantan Galur Sprague Dawley. Skripsi. Fakultas Kedokteran Dan Ilmu Kesehatan. Prodi Farmasi, 8, 372–379.

Izzati, U. Z. (2015). Efektivitas Penyembuhan Luka Bakar Salep Ekstrak Etanol Daun Senggani ( Melastoma malabathricum L .) pada Tikus ( Rattus norvegicus ) Naskah Publikasi oleh : Ulfa Zara Izzati Program Studi Farmasi. Naskah Publikasi, 6.

Kalangi, S. J. R. (2014). Histofisiologi Kulit. Jurnal Biomedik (Jbm), 5(3), 12–20. https://doi.org/10.35790/jbm.5.3.2013.4344

Lu, Q., Ma, R., Yang, Y., Mo, Z., Pu, X., & Li, C. (2020). Zanthoxylum nitidum (Roxb.) DC: Traditional uses, phytochemistry, pharmacological activities and toxicology. Journal of Ethnopharmacology, 260, 112946. https://doi.org/10.1016/j.jep.2020.112946

Lukitaningsih, E., Nur, S., Qonithah, F., Zulbayu, A., Kuswahyuning, R., & Rumiyati, R. (2020). In Vitro Anti-Wrinkle and Tyrosinase Inhibitory Activities of Grapefruit Peel and Strawberry Extracts. Majalah Obat Tradisional, 25(3), 182–189. https://doi.org/10.22146/mot.59194

Mery Sukmawati, Sumarto, C. W. (2013). The Effect of Andaliman Fruit (Zanthoxylum acanthopodium DC.) on uality of Smoked Catfisg (Pangasius hypopthalmus) Stored at Room temperature. Berkala Perikanan Terubuk, 41(1), 5–6.

Monuteaux, M. C., Fleegler, E. W., & Lee, L. K. (2017). A cross-sectional study of emergency care utilization and associated costs of violent-related (assault) injuries in the United States. Journal of Trauma and Acute Care Surgery, 83(2), 310–315. https://doi.org/10.1097/TA.0000000000001525

Palumpun, E. F., Wiraguna, A. A. G. P., Medicine, P. P. A., Penyakit, D., Andrologi, D., Kedokteran, F., & Udayana, U. (2017). Pemberian ekstrak daun sirih (Piper betle) secara topikal meningkatkan ketebalan epidermis, jumlah fibroblas, dan jumlah kolagen dalam proses penyembuhan luka pada tikus jantan galur Wistar (Rattus norvegicus. Jurnal E-Biomedik (EBm), 5.

Rahmawati, D., Febrina, E., & Tjitraresmi, A. (2016). Aktivitas Hipoglikemik Ekstrak Kulit Batang Matoa (Pometia Pinnata J.R. Forster & J.G. Forster) Pada Tikus Putih Jantan Galur Wistar Dengan Metode Toleransi sukrosa. Farmaka, 14(2), 97–111.

Rienoviar, R., & Setyaningsih, D. (2018). Studi Senyawa Aroma Ekstrak Andaliman (Zanthoxylum acanthopodium) dari Beberapa Pelarut Menggunakan Gas Chromatography - Mass Spectra (GC-MS). Warta Industri Hasil Pertanian, 35(2), 85. https://doi.org/10.32765/wartaihp.v35i2.4292

Sakamoto, T., Nishida, A., Wada, N., Nakamura, Y., Sato, S., Konishi, T., & Matsugo, S. (2020). Identification of a Novel Pyrrole Alkaloid from the Edible Mushroom Basidiomycetes-X (Echigoshirayukidake). Molecules (Basel, Switzerland), 25(21). https://doi.org/10.3390/molecules25214879

Saragih, D. E., & Arsita, E. V. (2019). Kandungan fitokimia Zanthoxylum acanthopodium dan potensinya sebagai tanaman obat di wilayah Toba Samosir dan Tapanuli Utara, Sumatera Utara. Prosiding Seminar Nasional Masyarakat Biodiversitas Indonesia, 5(1), 71–76. https://doi.org/10.13057/psnmbi/m050114

Sefanny, Nicki L, . (2020). Tentang Efektifitas Berkumur Ekstrak Andaliman 4% (Zanthoxyllum Acantopodium) Terhadap Penurunan Jumlah Bakteri Pada Siswa Sekolah SMA N 1 Medan. Fakultas Kedokteran Gigi Universitas Sumatera Utara.

Sitanggang, F. M. C., Duniaji, A. S., & Pratiwi, I. D. P. K. (2019). Daya Hambat Ekstrak Buah Andaliman (Zanthoxylum acanthopodium DC) dalam Etil Asetat terhadap Pertumbuhan Escherichia coli. Jurnal Ilmu Dan Teknologi Pangan, 8(3), 257–266.

Sumiati. (2017). Uji Aktivitas Salep Ekstrak Etanol Daun Jambu Biji (Psidium guajava Linn.) Terhadap Luka Bakar Derajat Ii Pada Tikus Jantan Putih. Jurnal Farmamedika (Pharmamedica Journal), 2(1), 40–48. https://doi.org/10.47219/ath.v2i1.32

Suryadi, I. A. (2013). Wound Healing Process and Wound Care. E-Jurnal Medika Udayana, 2(2), 254–272.

Tutik Rahayuningsih. (2012). Penatalaksanaan Luka Bakar (COMBUSTIO). PROFESI, 08(September), 32.

Winarti, W., Simanjuntak, P., & Syahidin, M. F. (2018). Identifikasi Senyawa Kimia Aktif Antioksidan Dari Ekstrak Etil Asetat Buah Andaliman (Zanthoxylum acanthopodium DC). Talenta Conference Series: Tropical Medicine (TM), 1(3), 162–166. https://doi.org/10.32734/tm.v1i3.283.




DOI: https://doi.org/10.33258/birex.v3i4.3054

Article Metrics

Abstract view : 1 times
PDF - 1 times

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
 

 

Statcounter for Budapest International Research in Exact Sciences (BirEx Journal)