The Healing Analysis of II Degree Burn from Surgery Essential Oil Ointment (Curcuma Longa) in Wistar Rats (Rattus Norvegicus)
Abstract
Data in Indonesia the death rate from burns is still high at around 40%, mainly caused by severe burns. The most potential medicinal turmeric plant is its rhizome, which contains the phenolic compound curcumin and essential oils. Some of the benefits of turmeric antioxidants, anti-inflammatory, anti-cancer, acetylcholinesterase activity inhibitors, anti-fungal, and anti-bacterial. This study aims to find out the phytochemical content and effects of Turmeric Essential Oil Ointment (Curcuma longa Linn) in curing grade II burns in Wistar rats (Rattus norvegicus). This type of research is experimental with a pre-post approach and post-test control group design. The study was conducted at Riwandi Pet Shop and Animal House March-May 2021. The research sample is turmeric (Curcuma longa) obtained from a traditional market in the city of Medan and identified in herbarium Medanese (MEDA), Laboratoirum Taxonomy of Plants, Department of Biology, Faculty of Mathematics and Natural Sciences (FMIPA), University of North Sumatra, Medan. The test animal is a Wistar strain rat with as many as 20 tails divided into 4 treatment groups, so each group consists of 5 rats. The results of the study contained significant differences in the epithelial period of the standard group, 10% turmeric ointment and 15% against the control group. However, in the turmeric ointment group and the standard group, there was no difference in epithelialization periods. This is evident from the value P < 0.05 (Value P = 0.029). The healing effects of burns possessed by Turmeric ointment are both 10% and 15% and nebacetin ointment as standard shows significant differences. Where the wound contraction rate of turmeric ointment is 15% better than nebacetin ointment as standard. But in both turmeric ointments, both 10% and 15% and nebacetin ointment as standard did not show significant differences in the parameters of the epithelial period.
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Akbik, Dania, Maliheh Ghadiri, Wojciech Chrzanowski, and Ramin Rohanizadeh. 2014. “Curcumin as a Wound Healing Agent.” Life Sciences 116(1):1–7.
Ariani, S. 2017. Stop Kanker, Cara Praktis Olah Tanaman Obat Kanker. Yogyakarta: Istana Media.
Avni, Tomer, Ariela Levcovich, Dean D. Ad-El, Leonard Leibovici, and Mical Paul. 2010. “Prophylactic Antibiotics for Burns Patients: Systematic Review and Meta-Analysis.” BMJ (Online) 340(7745):517.
Badan Penelitian Dan Pengembangan Kesehatan Kementerian Kesehatan RI. 2013. Riset Kesehatan Dasar 2013.
Budiman, Iwan, Jalan Prof, Drg Suria, Sumantri Mph, and No Bandung. 2015. “RIMPANG KUNYIT ( Curcuma Longa Linn .) terhadap Luka Insisi pada Mencit Swiss-Webster Jantan Dewasa Turmeric ( Curcuma Longa Linn .) Wound Healing Activity Towards Incision on Wound Model of Adult Swiss-Webster Male Mice 1 Fakultas Kedokteran , Universita.” Perpustakaan Maranatha Thesis.
Cobra, Lea Shella. 2019. “Skirining Fitokimia Ekstrak Sokhletasi Rimpang Kunyit (Curcuma Longa) Dengan Pelarut Etanol 96%.” Jurnal Ilmiah Kesehatan Karya Putra Bangsa 1(1):12–17.
Fitria, Meishinta, Deddy Saputra, and Gusti Revilla. 2014. “Pengaruh Papain Getah Pepaya Terhadap Pembentukan Jaringan Granulasi Pada Penyembuhan Luka Bakar Tikus Percobaan.” Jurnal Kesehatan Andalas 3(1):73–76.
Fitriani, Diah. 2014. “Pengaruh Ekstrak Kunyit Terhadap Peningkatan Jumlah Makrofag Pada Soket Pasca Pencabutan Gigi Cavia Cobaya.” 1–4.
Hakim, Ashilah Mumtaz. 2020. “Efektifitas Aloe Vera Terhadap Luka Bakar.” Jurnal Ilmiah Kedokteran Wijaya Kusuma 9(2):245.
Hartati, Sri Yuni. 2013. “Perkebunan_KhasiatKunyit.Pdf.” Warta Penelitian Dan Pengembangan Tanaman Industri 19(2):5.
Itokawa, Hideji, Qian Shi, Toshiyuki Akiyama, Susan L. Morris-Natschke, and Kuo Hsiung Lee. 2008. “Recent Advances in the Investigation of Curcuminoids.” Chinese Medicine 3:1–13.
Kalangi, Sonny J. R. 2014. “Histofisiologi Kulit.” Jurnal Biomedik (Jbm) 5(3):12–20.
Kocaadam, Betül, and Nevin Şanlier. 2017. “Curcumin, an Active Component of Turmeric (Curcuma Longa), and Its Effects on Health.” Critical Reviews in Food Science and Nutrition 57(13):2889–95.
L.A. Usman. 2009. “Chemical Composition of Rhizome Oil of Curcuma Longa.Pdf.” World Journal of Chemistry 4(2):171–81.
Lia Fikayuniar, Neni Sri Gunarti, and Mellya Apriliani. 2019. “Uji Aktivitas Antibakteri Ekstrak Etanol Rimpang Kunyit (Curcuma Longa L.) terhadap Staphylococcus Aureus dan Pseudomonas Aeruginosa.” Pharma Xplore : Jurnal Ilmiah Farmasi 4(1):278–87.
Manarin, Gabriel, Daniela Anderson, Jorgete Maria e. Silva, Juliana da Silva Coppede, Persio Roxo-Junior, Ana Maria Soares Pereira, and Fabio Carmona. 2019. “Curcuma Longa L. Ameliorates Asthma Control in Children and Adolescents: A Randomized, Double-Blind, Controlled Trial.” Journal of Ethnopharmacology 238:111882.
Muthia Milasari, et al. 2019. “Pengaruh Pemberian Salep Ekstrak Kunyit Kuning (Curcuma Longa Linn) terhadap Penyembuhan Luka Sayat pada Tikus Putih (Rattus Norvegicus).” Jurnal Ilmiah Ibnu Sina 4(1):1–5.
Mutia, Levina. 2015. “Tirah Baring Di Ruang Rawat Inap Rsud Arifin Achmad Provinsi Riau Periode Januari 2011- Desember 2013.” Jom Fk 2(2):1–11.
Nabofa, Williams E. E., Oluwadamilola O. Alashe, Oyetunde T. Oyeyemi, Alfred F. Attah, Ademola A. Oyagbemi, Temidayo O. Omobowale, Adeolu A. Adedapo, and Akinola R. A. Alada. 2018. “Cardioprotective Effects of Curcumin-Nisin Based Poly Lactic Acid Nanoparticle on Myocardial Infarction in Guinea Pigs.” Scientific Reports 8(1):1–11.
Nadifah, Fitri, Nurlaili Farida Muhajir, and Fitri Retnoningsih. 2018. “Daya Hambat Minyak Atsiri Rimpang Kunyit Terhadap Pertumbuhan Candida Albicans In Vitro.” Jurnal Vokasi Kesehatan 4(1):1.
Negi, Jagmohan, R. Bisht, and S. Kandari Negi. 2012. “Major Constituents, Antioxidant and Antibacterial Activities of Zanthoxylum Armatum DC. Essential Oil.” Iranian Journal of Pharmacology and Therapeutics 11(2):68–0.
Panghiyangani, Roselina. 2010. “Aktivitas Larvisida Minyak Atsiri Rimpang Kunyit Putih (Curcuma Zedoaria) Terhadap Larva Aedes Aegypti.” Majalah Kedokteran FK UKI 2010 XXVII(3).
Phillips, Steven J. 2000. “Physiology of Wound Healing and Surgical Wound Care.” ASAIO Journal 46(6):2–5.
Razavi, et al. 2021. “A Review of Therapeutic Potentials of Turmeric (Curcuma Longa) and Its Active Constituent, Curcumin, on Inflammatory Disorders, Pain, and Their Related Patents.” Phytotherapy Research (July):1–25.
Sabale, Prafulla, Arjun Modi, and Vidya Sabale. 2013. “Curcuma Longa Linn. A Phytochemical and Phytopharmacological Review.” Research Journal of Pharmacognosy and Phytochemistry 5(2):59–68.
Safwan, Safwan, Sapto Yuliani, and Suwidjiyo Pramono. 2014. “Uji Aktivitas Minyak Atsiri Rimpang Kunyit (Curcuma Longa Linn) pada Tikus Sprague Dawley Model Demensia (Kajian Penghambat Aktivitas Asetilkolinesterase).” Kartika Jurnal Ilmiah Farmasi 2(2):20–26.
Setiadi, Adi, Nurul Khumaida, and Dan Sintho Wahyuning Ardie. 2017. “Keragaman Beberapa Aksesi Temu Hitam (Curcuma Aeruginosa Roxb.) Berdasarkan Karakter Morfologi.” Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) 45(1):71–78.
Setyopuspito Pramitaningastuti, Anastasia. 2017. “Uji Efektivitas Antiinflamasi Ekstrak Etanol Daun Srikaya (Annona Squamosa. L) Terhadap Edema Kaki Tikus Putih Jantan Galur Wistar.” Jurnal Ilmiah Farmasi 13(1):8–14.
Sirwutubun, Magdalena, Maya M. Ludong, Dekie Rawung, Jurusan Teknologi Pertanian, Fakultas Pertanian, Universitas Sam, and Ratulangi Manado. 2016. “Karakteristik Ekstrak Pewarna Alami Buah Merah ( Pandanus Conoideus Lamk .) Dan Aplikasinya Pada Produk Pangan.” Jurnal Teknologi Pertanian 7(5):1–8.
Thakur, Rupesh, Nitika Jain, Raghvendra Pathak, and Sardul Singh Sandhu. 2011. “Practices in Wound Healing Studies of Plants.” Evidence-Based Complementary and Alternative Medicine 2011.
Tutik Rahayuningsih. 2012. “Penatalaksanaan Luka Bakar (Combustio).” Profesi 8:32.
Verma, Deepak Kumar, Masuram Bharat, Depaak Nayak, Tara Shanbhag, Venkatesh Shanbhag, and Ravindra Singh Rajput. 2012. “Areca Catechu : Effect of Topical Ethanolic Extract on Burn Wound Healing in Albino Rats.” International Journal Pharmacology and Clinical Sciences 1(3):74–78.
Wanninger, Simon, Volker Lorenz, Abdus Subhan, and Frank T. Edelmann. 2015. “Metal Complexes of Curcumin - Synthetic Strategies, Structures and Medicinal Applications.” Chemical Society Reviews 44(15):4986–5002.
Young, Alistair, and Clare Ellen McNaught. 2011. “The Physiology of Wound Healing.” Surgery 29(10):475–79.
Zorofchian Moghadamtousi, Soheil, Habsah Abdul Kadir, Pouya Hassandarvish, Hassan Tajik, Sazaly Abubakar, and Keivan Zandi. 2014. “A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin.” BioMed Research International 2014.
DOI: https://doi.org/10.33258/birex.v4i1.3474
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