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Anti-Dislipidemia Effectiveness Test of Turmeric Ethanol Extract (Curcuma Longa) in Male Wistar Mice Given Propylthiouracil (PTU)
Abstract
Dyslipidemia is a lipid metabolic disorder that is a risk factor for coronary heart disease (CHD). According to the American Heart Association, data from 2013 to 2016, as many as 92.8 million adults in America have total cholesterol of more than 200 mg / dL. Curcumin, the main compound in turmeric, can lower cholesterol levels due to inhibiting the reabsorption of cholesterol derived from the outside (exogenous) and increasing the enzyme HMG-CoA reductase inhibitor so that fat synthesis can run well. The purpose of this study was to find out the effectiveness of mangosteen peel ethanol extract as an anti-dyslipidemia in male Wistar rats given Propylthiouracil (PTU). This study is an experimental study with a Pre-test and Post-test group only control design approach that uses male Wistar rats as test animals and turmeric extract. The study was conducted in March 2021, at the Herbarium Medanese FMIPA USU, the Pharmacognosy Laboratory of the FACULTY of Pharmacy USU, and the Laboratory of Pharmaceutical Pharmacology USU. Descriptive data analysis (Central tendency and Dyspersi) in the form of lipid profiles (LDL, HDL, Total Cholesterol, and Triglycerides), color, texture, weights. Then analyzed with One-Way Anova if the distributed data is normal, if the distributed data is not normal, then the Kruskal-Wallis test is used. The results and conclusions, turmeric ethanol extract (Curcuma Longa) III (151.70 ± 0.95 mg/dl) can significantly decrease total cholesterol compared to the control group (178.50 ± 6.05mg/dl) (P-value < 0.05). Turmeric ethanol extract (Curcuma Longa) III (110.00 ± (109-112) mg/dl) may significantly lower triglyceride levels compared to the control group (167.00 (162-179) mg/dl). (Value P = 0.027). Turmeric ethanol extract (Curcuma Longa) III (68.50 ± 1.28 mg/dl) significantly lowered LDL levels compared to the control group (107.20 ± 3.60 mg/dl). (P-value < 0.05). Turmeric ethanol extract (Curcuma Longa) III, (61.00 (60-62) mg/dl) may significantly increase HDL levels compared to the control group (28.50 (37-45) mg/dl). (Value P = 0.027). Turmeric ethanol extract (Curcuma Longa) III significantly lowered SGOT (Value = 0.027) and SGPT (Value P < 0.05) compared to the control group.
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Abarikwu, S. O. et al. (2020) ‘Evaluation of the protective effects of quercetin and gallic acid against oxidative toxicity in rat’s kidney and HEK-293 cells’, Toxicology Reports, 7(February), pp. 955–962. doi: 10.1016/j.toxrep.2020.07.015.
Aldahmash, B. A. and El-Nagar, D. M. (2016) ‘Antioxidant Effects of Captopril against Lead Acetate-Induced Hepatic and Splenic Tissue Toxicity in Swiss Albino Mice’, Saudi Journal of Biological Sciences, 23(6), pp. 667–673. doi: 10.1016/j.sjbs.2016.05.005.
Aparicio, H. J. et al. (2021) Heart Disease and Stroke Statistics-2021 Update A Report from the American Heart Association, Circulation. doi: 10.1161/CIR.0000000000000950.
Ardhani, S. et al. (2017) ‘Efektivitas Ekstrak Kunyit (Curcuma domestica) Sebagai Terapi Non Farmakologi Dislipidemia dan Antiaterosklerosis’, Medula, 7(5), pp. 194–198.
Bahri, S., Pasaribu, F. and Sitorus, P. (2012) ‘Uji Ekstrak Etanol Kulit Buah Manggis (Garcinia Mangostana ,L) Terhadap Penurunan Kadar Glukosa Darah’, Journal of Pharmaceutics and Pharmacology, 1(1), pp. 1–8.
Batubara, M. S., Sabri, E. and Tanjung, M. (2017) ‘Pengaruh Pemberian Ekstrak Etanol Daun Andaliman (Zanthoxylum acanthopodium DC.) terhadap Gambaran Morfologi Ovarium Mencit (Mus musculus L.) Strain DDW’, Klorofil, 1(1), pp. 5–10.
D’Agostino, R. B. et al. (2008) ‘General cardiovascular risk profile for use in primary care: The Framingham heart study’, Circulation, 117(6), pp. 743–753. doi: 10.1161/CIRCULATIONAHA.107.699579.
Dipiro J et al. (2015) Pharmacoterapy A Phatophysiologic Approach, AIAA Guidance, Navigation, and Control Conference.
El-Sayed, E. M. et al. (2011) ‘Cardioprotective effects of Curcuma longa L. extracts against doxorubicin-induced cardiotoxicity in rats’, Journal of Medicinal Plants Research, 5(17), pp. 4049–4058.
Feldman, F. et al. (2021) ‘Efficacy of polyphenols in the management of dyslipidemia: A focus on clinical studies’, Nutrients, 13(2), pp. 1–42. doi: 10.3390/nu13020672.
Fouad, A. A. and Jresat, I. (2013) ‘Captopril and telmisartan treatments attenuate cadmium-induced testicular toxicity in rats’, Fundamental and Clinical Pharmacology, 27(2), pp. 152–160. doi: 10.1111/j.1472-8206.2011.00974.x.
Gustomi Rima, M. P. L. (2015) ‘Ekstrak Rimpang Kunyit Menurunkan Kadar Lemak Darah Pasien Hiperlipidemia (Turmeric (Curcuma Longa Linn) Extract Toward Modification of Blood Lipid Level in Hyperlipidemia Patients)’, Journals of Ners Community, 6(Vol 6, No 1 (2015)), pp. 1–7. Available at: http://journal.unigres.ac.id/index.php/JNC/article/view/66.
Irmadoly, N. et al. (2014) ‘Uji Aktivitas Antidislipidemia In Vivo Fraksi Ekstrak Daun Salam ( Eugenia polyantha ) pada Tikus Galur Wistar yang diinduksi Diet Tinggi Lemak’, Jurnal Kedokteran dan Kesehatan, 1(1), pp. 21–24.
Jijith, U. S. and Jayakumari, S. (2018) ‘Screening methods for antihyperlipidemic activity : A review’, 10(2), pp. 2017–2019.
Kemenkes RI (2018) ‘Hasil Riset Kesehatan Dasar Tahun 2018’, Kementrian Kesehatan RI, 53(9), pp. 1689–1699.
Komang, N. and Laksmi, S. (2014) ‘Continuing Continuing Development Professional Medical Development’, 41(11), pp. 823–827.
Kosasih, E. et al. (2019) ‘Hepatoprotective Effect of Citrus Sinensis Peel Extract Against Isoniazid and Rifampicin-induced Liver Injury in Wistar Rats’, Majalah Obat Tradisional, 24(3), pp. 197–203. doi: 10.22146/mot.45762.
Manarin, G. et al. (2019) ‘Curcuma longa L. ameliorates asthma control in children and adolescents: A randomized, double-blind, controlled trial’, Journal of Ethnopharmacology, 238, p. 111882. doi: 10.1016/j.jep.2019.111882.
Mutia, M. S. and Chiuman, L. (2019) ‘Hepatoprotective Effect of Citrus sinensis ( L .) Osbeck Ethanol Extract in Paracetamol-Induced Rats Efek Hepatoprotektif Ekstrak Etanol Citrus sinensis L . Osbeck pada Tikus yang Diinduksi Parasetamol’, Majalah Kedokteran Bandung, 51(4), pp. 189–193.
Olayinka, E. T. et al. (2014) ‘Protective effect of quercetin on melphalan-induced oxidative stress and impaired renal and hepatic functions in rat’, Chemotherapy Research and Practice, 2014. doi: 10.1155/2014/936526.
Rezzani, R., Franco, C. and Rodella, L. F. (2019) ‘Curcumin as a therapeutic strategy in liver diseases’, Nutrients, 11(10), pp. 1–7. doi: 10.3390/nu11102498.
Sabale, P., Modi, A. and Sabale, V. (2013) ‘Curcuma longa Linn. A Phytochemical and Phytopharmacological Review’, Research Journal of Pharmacognosy and Phytochemistry, 5(2), pp. 59–68.
Shishodia, S. et al. (2005) ‘Curcumin (diferuloylmethane) inhibits constitutive NF-κB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma’, Biochemical Pharmacology, 70(5), pp. 700–713. doi: 10.1016/j.bcp.2005.04.043.
Subhawa Harsa, I. M. (2014) ‘Efek Pemberian Diet Tinggi Lemak Terhadap Profil Lemak Darah Tikus Putih (Rattus norvegicus)’, Universitas Wijaya Kusuma, 31, pp. 21–28.
Sun, Y. E., Wang, W. and Qin, J. (2018) ‘Anti-hyperlipidemia of garlic by reducing the level of total cholesterol and low-density lipoprotein’, Medicine (United States), 97(18), pp. 1–8. doi: 10.1097/MD.0000000000010255.
Taufik, F. (2020) ‘Skripsi 2020’.
Thong, V. D. and Quynh, B. T. H. (2021) ‘Correlation of serum transaminase levels with liver fibrosis assessed by transient elastography in vietnamese patients with nonalcoholic fatty liver disease’, International Journal of General Medicine, 14, pp. 1349–1355. doi: 10.2147/IJGM.S309311.
Untari, M. K. and Pramukantoro, G. E. (2020) ‘Aktivitas Antihiperkolesterolemia Ekstrak Etanol Daun Stevia Rebaudiana Bertoni Pada Tikus Putih Jantan’, Journal Syifa Sciences and Clinical Research, 2(1), pp. 11–20. doi: 10.37311/jsscr.v2i1.2700.
Widowati, W. et al. (2016) ‘Antioxidant and Anti Aging Assays of Oryza sativa Extracts, Vanillin and Coumaric Acid’, Journal of Natural Remedies, 16(3), pp. 88–99. doi: 10.18311/jnr/2016/7220.
Widowati, W. et al. (2017) ‘Antioxidant and antiaging assays of Hibiscus sabdariffa extract and its compounds’, Natural Product Sciences, 23(3), pp. 192–200. doi: 10.20307/nps.2017.23.3.192.
Widowati, W. et al. (2018) ‘Antioxidant and antiaging activities of Jasminum sambac extract, and its compounds’, Journal of Reports in Pharmaceutical Sciences, 7(3), pp. 270–285.
Worotikan, R. V., Tuju, E. A. and Kawuwung, F. (2017) ‘Analisa Efektivitas Antidiabetes Ekstrak Etanol Buah Andaliman (Zanthoxylum acanthopodium DC) pada Histopatologi Ginjal Tikus Putih (Rattus norvergicus) yang Diinduksi Alloksan’, Jurnal Sains Matematika & Edukasi, 5(1), pp. 29--37.
Wulansari, F. (2020) ‘Aktivitas Water Kefir sebagai Antidislipidemia pada Tikus Putih Jantan yang Diinduksi Propylthiouracil (Ptu) dan Emulsi Lemak’, Universitas Bhakti Kencana Fakultas Farmasi Program Strata I Farmasi Bandung 2020, Laporan Tu, pp. 5–24.
Yunarto, N. et al. (2019) ‘Aktivitas Antioksidan serta Penghambatan HMG CoA dan Lipase Kombinasi Ekstrak Daun Binahong-Rimpang Temulawak Antioxidant Activity along with Inhibition of HMG CoA Reductase and Lipase from Anredera cordifolia Leaf - Curcuma xanthorrhiza Rhizome Combinati’, 9(2), pp. 89–96.
DOI: https://doi.org/10.33258/birex.v4i1.3475
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