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Assessing the Difference in Time to Increase Hemoglobin Levels at 1 hour, 6 hours, and 12 hours after Blood Transfusion in Thalassemia Patients at the Regional General Hospital Dr. Zainoel Abidin Banda Aceh
Abstract
Thalassemia is a congenital blood disorder characterized by reduced production of one or more globin chains. Thalassemia patients lack healthy hemoglobin which the body needs to be properly oxygenated. Blood transfusion is the main treatment for thalassemia patients. Checking hemoglobin levels after transfusion is a common test, but until now there is no definite uniformity of time to carry out these tests, so it will be detrimental to the patient and increase the length of the patient in the hospital. Assessing the difference in time to increase in hemoglobin levels at 1 hour, 6 hours, and 12 hours after blood transfusion in thalassemia patients. This research is an observational analytic study with cross sectional design. This study was conducted by examining the hemoglobin levels of thalassemia patients after 1 hour, 6 hours, and 12 hours after transfusion in thalassemia patients aged 1-18 years with a total sample of 40 people. The statistical analysis used was paired t test. The results showed that 20 men and 20 women and Most were in the age group 10-13 (35%), with an average Hb level at admission of 7.38 g / dL (95% CI). At 1 hour post-transfusion, the patient's mean Hb level increased by 8.97 g / dL (8,59-9,35 g / dL), at 6 hours post transfusion, 8.95 g / dL (8,57-9,32 g / dL), at 12 hours post transfusion increased by 9.60 g / dL (9,17-10,03 g / dL). Significant increase in Hb levels occurred at 1 hour and 12 hours after blood transfusion.
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Agarwal, Anurag K, Paul, Rai, Shannon K. Unique aspects of red blood cell transfusion in pediatric patients. Int J Clin Transfus Med. 2016;4:43–54.
Andriastuti M, Sari TT, Wahidiyat P, Putriasih S. Kebutuhan Transfusi Darah Pasca-Splenektomi pada Thalassemia Mayor. Sari Pediatr. 2011;13:244–9.
Audu LI, Otuneye AT, Mairami AB, Mselia LJ, Nwatah V. Posttransfusion Haematocrit Equilibration: Timing Posttransfusion Haematocrit Check in Neonates at the National Hospital, Abuja, Nigeria. Int J Pediatr. 2015;1–5.
Cappellini MD, Cohen A, Porter J, Taher A, Vibrakasit V. Guidelines For The Management Of Transfusion Dependent. Edisi 3. Nicosia, Cyprus: Thalassemia International Federation; 2014; h. 14-26
DeBaun MR, Jones, Melissa JF, Vichinsky E. Thalassemia syndromes. Dalam: Robert M. Kliegman, editor. Nelson Textbook of Pediatrics. Edisi 20. Philadelphia; 2016. h. 2349–52.
Elizalde JL, Clemente J, Martin JL, Panes J, Aragon B, Mas A, dkk. Early changes in hemoglobin and hematocrit levels after packed red cell transfusion in patients with acute anemia. Transfusion. 1997;37:573–6.
Ermaya YS, Hilmanto D, Reniarti L. Hubungan Kadar Hemoglobin Sebelum Transfusi dan Zat Pengikat Besi dengan Kecepatan Pertumbuhan Penderita Thalassemia Mayor. 2007;57;380–4.
Gani, A., and Jailani, M. (2020). Priapism in Patients Chronic Myeloid Leukemia. Budapest International Research in Exact Sciences (BirEx) Journal Vol 2 (4): 443-451.
Glatstein M, Oron T, Barak M, Mimouni FB, Dollberg S. Posttransfusion equilibration of hematocrit in hemodynamically stable neonates. Pediatr Crit Care Med. 2005;6:707–8.
Hamizah L, Susanah S, Rakhmilla LE. Clinical Manifestations Of Children With Thalassemia Major : Clinical Course One Year Later. Asian J Biol Med Sci. 2017;3:h.1–11.
Hoque MM, Adnan SD, Karim S, Mamun MA Al, Nandy S, Faruki M Al, dkk. Equilibration and Increase of Hemoglobin Concentration after One Unit Whole Blood Transfusion among Patients Not Actively Bleeding. J Dhaka Med Coll. 2015;23:161–6.
Isworo A, Setiowati D, Taufik A. Kadar hemoglobin, status gizi, pola konsumsi makanan dan kualitas hidup pasien thalassemia. J Kep Soedirman. 2012;7:183–9.
Karndumri K, Tantiworawit A, Hantrakool S, Fanhchaksai K. Transfusion and Apheresis Science - Comparison of hemoglobin and hematocrit levels at 1 , 4 and 24 h after red blood cell transfusion. Transfus Apher Sci [Internet]. 2020;59-60. Diunduh dari: https://doi.org/10.1016/j.transci.2019.06.021. Diakses pada 14 juni 2020.
Keputusan Menteri Kesehatan Republik Indonesia. Nomor HK.01.07/Menkes/1/2018 : Pedoman Nasional Pelayanan Kedokteran Tatalaksana Thalasemia. 2018;1-90.
Lal A, Wong TE, Andrews J, Balasa VV, Chung JH, Forester CM, dkk. Transfusion practices and complications in thalassemia. Transfusion. 2018;58:2826–35.
Linda R, Ninda D. Differences in changes of hemoglobin between 6-12 hours and 12-24 haours after transfusion. Maj Patol Klin Indones dan Lab Med. 2018;24:108–11.
Nikmah M, Mauliza. Kualitas Hidup Penderita Talasemia berdasarkan Instrumen Pediatric Quality of Life Inventory 4.0 Generic Core Scales di Ruang Rawat Anak Rumah Sakit Umum Cut Meutia Aceh Utara. Sari Pediatr. 2018;20:11–16.
New HJ, Berryman J, Bolton-maggs PHB, Chalmers EA, Davies T, Gottstein R, dkk. Guidelines on transfusion for fetuses , neonates and older children British Society for Haematology. Br Soc Heamotology. 2016;1–91.
Raja A, Jain A, Marwaha N, Trehan A. Transfusion and Apheresis Science - Comparison of efficacy of packed red blood cell transfusion based on its hemo globin content versus the standard transfusion practice in thalassemia major patients ( HEMOCON study ). Transfus Apher Sci [Internet]. 2020;1:1–6.. Diunduh dari: https://doi.org/10.1016/j.transci.2020.102736. Diakses pada 14 juni 2020.
Shander A, Gross I, Hill S, Javidroozi M, Sledge S. A new perspective on best transfusion practices. Blood Transfus. 2013;11:193–202.
Siska SP. Gambaran kadar hemoglobin sebelum dan sesudah transfusi darah pada pasien anemia di RSUD DR. M. Zein Painan (skripsi). Padang : Sekolah Tinggi Ilmu Kesehatan Perintis, 2019.
Tari K, Ardalan PV, Abbaszadehdibavar M, Atashi A, Jalili A, Gheidishahran M. Thalassemia an update: molecular basis, clinical features and treatment. Int J BioMed Public Health. 2018;1:48–58.
Wahidiyat PA, Permono B. Hemoglobinopati dan Talasemia. Dalam: Windiastuti E, Nency YM, Mulatsih S, Sudarmanto B, Ugrasena IDG, editor. Buku Ajar Hemato Onkologi Anak Edisi Revisi. 2018.h. 60–80.
Wahidiyat PA, Permono B. Hemoglobinopati dan Talasemia. Dalam: Windiastuti, E. Nency YM,, Mulatsih S, Sudarmanto B, Urgasena IDG, editor. Buku Ajar Hemato Onkologi Anak. Edisi Revisi. Jakarta: Badan Penerbit Ikatan Dokter Anak Indonesia; 2018. h. 60–79.
Wiesen AR, Hospenthal DR, Byrd JC, Glass KL, Howard RS, Diehl LF. Equilibration of hemoglobin concentration after transfusion in medical inpatients not actively bleeding. Ann Intern Med. 1994;121:278–80.
DOI: https://doi.org/10.33258/birex.v3i2.1809
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