Initial Screening of Thyroid Function Test in Premature and Term Infants at General Hospital Dr. Zainoel Abidin Banda Aceh

Pretyca Yudra Perdana, Dora Darussalam, Rusdi Andid, Mulya Safri, Syafruddin Haris, Nora Sovira

Abstract


Congenital hypothyroidism (CH) is the most common cause of mental retardation which can be prevented by early diagnosis and treatment. Premature infants have a higher risk of developing HK than term infants. Screening for CH in every newborn is important, however, in premature babies screening for CH using the TSH examination is often found to have normal levels in the first week of examination. This study is a cross sectional study where the research sample amounted to 62 infants who were divided into 2 groups, namely premature babies (n = 31) and term infants (n = 31). Statistical analysis used is Independent sample t test and Mann-Whitney U test. This study aims to assess the comparison of thyroid function (FT4 and TSHs) between premature infants and term infants at the first examination in the age range of 2 -6 days. The results showed that 90% (28/31) premature infants had hypothyroxinemia with lower FT4 levels than term infants (18.70 ± 6.50, 95% CI). TSHs levels in premature infants were higher than term infants (5.70 ± 5.27, 95% CI). This study concluded that FT4 is better at detecting thyroid function disorders in premature infants while TSHs are better at detecting abnormal thyroid function in term infants.


Keywords


Congenital hypothyroidism; congenital hypothyroidism in preterm baby; thyroid function in preterm baby; congenital hypothyroidism screening

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References


Agrawal P, Philip R, Saran S, Gutch M, Razi MS, Agrolya P dkk. Congenital hypothyroidism.IJEM. 2015;19:221-8.

Chung HR. Screening and management of thyroid dysfunction in preterm infants. Ann Pediatr Endocrinol Metab. 2019;24:15–21.

Chung HR, Shin CH, Yang SW, Choi CW, Kim B Il, Kim EK, dkk. High incidence of thyroid dysfunction in preterm infants. J Korean Med Sci. 2009;24:627–31.

Chung ML. Incidence and risk factor of permanent hypothyroidism in preterm infants. J Neonatal Biol. 2017;06:2–5.

Clemente M, Cuevas PR, Carrascosa A, potau N, Almar J, Salcedo S, dkk. Thyroid function in preterm infants 27-29 weeks of gestational age during the first four months of life: results from a prospective study comprising 80 preterm infants. J Pediatr Endocrinl Metab.2007; 20: 1269-80.

Frank JE, Faix JE, Hermos RJ, Mullaney DM, Rojan DA, Mitchell ML, dkk. Thyroid fuction in very low birth weight infants: effects on neonatal hypothyroidism screening. J Pediatr. 1996;128:548-54.

Hallett A, Evans C, Moat S, Barton J, Warner J, Gregory JW. Hypothyroidism in preterm infants following normal screening. Ann Clin Biochem. 2011;48:572–4.

Iqbal T, Ali MOI, Atia N, Islam T. Study of Thyroid Hormone Status in Normal Newborn and Preterm, Low Birth Weight Baby. KYAMC Journal. 2017;7:787-90.

Julia M, Rustama DS. Hipotiroid kongenital. Dalam:Batubara JRL,Tridjaja B, Pulungan AB, penyunting. Buku Ajar Endokrinologi Anak. Edisi ke-2. Jakarta:Badan Penerbit Ikatan Dokter Anak Indonesia;2018. h. 256-76.

Kementerian Kesehatan Republik Indonesia. Peraturan Menteri Kesehatan Republik Indonesia no 78 tentang Skrinning Hipotiroid Kongenital. Diunduh dari: https://persi.or.id/wp-content/uploads/2020/11/pmk782014.pdf. Diakses Desember 2018.

LaFranchi S. Thyroid function in the preterm infant. Thyroid. 1999;9:71–8.

McGrath N, Hawkes CP, Mayne P, Murphy NP. Optimal timing of repeat newborn screening for congenital hypothyroidism in preterm infants to detect delayed thyroid-stimulating hormoneelevation. J Pediatr. 2019;205:77–82.

Moraes SH, Espiridiao S, Fonseca FA, Abreu LC, Valenti VE, Souto RP. Collection time of thyroid hormones and TSH in preterm newborns.HealthMED. 2011;5:627-32.

Murphy N, Hume R, Toor HV, Matthews TG, Ogston SA, Wu SY, dkk. The hypothalamic-pituitary-thyroid axis in preterm infants; changes in the first 24 hours of postnatal life. J Clin Endocr Metab.2004;89:2824-31.

Rovet J, Daneman D. Congenital hypothyroidism: a review of current diagnostic and treatment practices in relation to neuropsychologic outcome. Paediatr Drugs. 2003;5:141–9.

Scavone M, Giancotti L, Anastasio E, Pensabene L, Sestito S, Concolino D. Evolution of congenital hypothyroidism in a cohort of preterm born children. Pediatr Neonatol. 2020; 61:629-36.

Sharma JD, Nazir MFH, Khan AG, Hoque B. Does hypothyroxinemia of preterm neonates persist beyond 7 week of life?.Indian J Pediatr. 2019;86:686-91.

Srinivasan R, Cheetham T, Harigopal S, Wastell H. Repeat testing of TSH in preterm infant for congenital hypothyroidism. Arch Dis Child. 2011;96:27.

Watson S. Congenital hypothyroidism. Healthline [internet].2018 [dikutip Desember 2018]. Tersediapada: https://www.healthline.com/health/congenital-hypothyroidism

Woo HC, Lizarda A, Tucker R, Mitchell ML, Vohr B, Oh W, dkk. Congenital hypothyroidism with a delayed thyroid-stimulating hormone elevation in very premature infants: incidence and growth and developmental outcomes. JPEDS. 2011;158: 538-42.

Yati NP, Utari A, Rustama DS, Soenggoro EP, Marzuki ANS, Soesanti F, dkk. Diagnosis dan tata laksana hipotiroid kongenital. Dalam: Yati NP, Utari A, Tridjaja B, penyunting. Panduan praktik klinis ikatan dokter anak Indonesia. Jakarta: Badan Penerbit Ikatan Dokter Anak Indonesia; 2017. h.1-10.




DOI: https://doi.org/10.33258/birex.v3i4.2646

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