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Effectiveness of Ethanol Extract Mangosteen Peel (Garcinia Mangostana L.) in Accelerating Post-Tooth Extraction Healing in Wistar Rats
Abstract
Tooth extraction will cause a wound in the form of alveolar bone that opens in the oral cavity. Mangosteen peel has various pharmacological effects such as anti-inflammatory, antioxidant, antidiabetic, and antibacterial. The goal of this study was to find out the effectiveness of Mangosteen Peel Ethanol Extract (Garcinia mangostana L.) 45% with 90% in speeding up the healing time of post-tooth extraction wounds in Wistar rats. This type of research is an experimental laboratory with a post-test pattern only control group design. Conducted at the Laboratory of Pharmacology & Laboratory of Traditional Medicine Faculty of Pharmacy, University of North Sumatra January-March 2021. The animal is a male Wistar rat of 32 who is physically healthy. The size of the sample is determined by Federer's formula, the minimum sample size for each treatment is 16 rats. The results of the study that there is a significant relationship between the amount of fibroblast tissue per field of view in Wistar Rats after tooth extraction with the administration of mangosteen peel (Garcinia mangostana L.) with a concentration of 45% and mangosteen peel (Garcinia mangostana L.) concentration 90%, p = 0.036 (p<0.05). Mangosteen skin extract (Garcinia mangostana L.) is 45% and 90% effective in speeding up wound healing time after extraction of rat teeth Wistar. Mangosteen skin extract (Garcinia mangostana L.) is 90% more effective than turmeric extract (Curcuma longa) 45% in speeding up wound healing time post-extraction of rat teeth Wistar due to the flavonoid content in mangosteen skin extract (Garcinia mangostana L.) 90% which helps accelerate wound healing higher than skin extract Mangosteen (Garcinia mangostana L.) 45%.
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Aryati, Yosephine Vania Prima, Iwan Setiawan, Nofi Risa Ariani, and Diah Dwi Hastuti. 2018. “Pengaruh Gel Kombinasi Ekstrak Kulit Semangka ( Citrullus Lanatus( Thunb.)) Dan Ekstrak Kulit Manggis (Garcinia Mangostana L.) Terhadap Penyembuhan Luka Bakar Pada Kelinci.” JPSCR : Journal of Pharmaceutical Science and Clinical Research 3(2):117.
Bahri, S., F. Pasaribu, and P. Sitorus. 2012. “Uji Ekstrak Etanol Kulit Buah Manggis (Garcinia Mangostana ,L) Terhadap Penurunan Kadar Glukosa Darah.” Journal of Pharmaceutics and Pharmacology 1(1):1–8.
Chin, Young-Won. 2011. “A Popular Botanical Dietary Supplement.” Mini Rev Org Chem 5(4):355–64.
Dr. Gede Wirata, S. Ke. 2018. “Perubahan Fibroblas Pada Penuaan.” 6(1):102–6.
Fitriyah, Nikmatul, Mahendrata K. Purwa, M. Afif Alfiyanto, Nila Wahuningsih, and Joko Kismanto. 2013. “Obat Herbal Antibakteri Ala Tanaman Binahong.” Jurnal KesMaDaSka 116–22.
HM, Chandra. 2014. Buku Petunjuk Praktis Pencabutan Gigi (1st Ed). Makassar: Sagung Seto.
Kemala, Dwita, Ina Hendiani, and Mieke Hemiawati Satari. 2018. “Uji Daya Antibakteri Ekstrak Etanol Kulit Buah Manggis (Garcinia Mangostana L) Terhadap Streptococcus Sanguinis ATCC 10556.” Padjadjaran Journal of Dental Researchers and Students 2(2):137.
Khairani, Tetty Noverita, Ruth Mayana Rumanti, Afri Manao, Dosen Farmasi, Fakultas Farmasi, Institut Kesehatan Helvetia, Mahasiswa Farmasi, Fakultas Farmasi, Institut Kesehatan Helvetia, Tetty Noverita, Khairani Institut, Kesehatan Helvetia, Jl Kapten, and Sumarsono No. 2020. “Formulasi Sediaan Krim Ekstrak Etanol Kulit Buah Manggis ( Garcinia Mangostana L .) sebagai Obat Luka Bakar pada Tikus Putih Jantan Cream Formulation of Ethanol Extract Of Mangosteen Peel ( Garcinia Mangostana L .) As A Burn Healing In White Male Rats Ala.” 4(2):53–58.
Kusmita, Lia, Ika Puspitaningrum, Fakultas Famasi, Sekolah Tinggi Ilmu Farmasi, and Yayasan Pharmasi. 2014. “Uji Aktivitas Gel Ekstrak Etanol Kulit Buah Manggis (Garcinia Mangostana L.) sebagai Penyembuh Luka Bakar pada Kulit Punggung Kelinci Activity of Gel Mangosteen Rind Aethanol Extract (Garcinia Mangostana L.) Toward Burns Healing On Skin Rabbit.” Media Farmasi Indonesia 9(1):606–15.
Lande, Randy, Billy J. Kepel, and Krista V. Siagian. 2015. “Gambaran Faktor Risiko Dan Komplikasi Pencabutan Gigi Di Rsgm Pspdg-Fk Unsrat.” E-GIGI 3(2).
Marchianti, Ancah., Elly. Nurus Sakinah, and Nunad. et al. Diniyah. 2017. “Digital Repository Universitas Jember Digital Repository Universitas Jember.” Efektifitas Penyuluhan Gizi Pada Kelompok 1000 HPK Dalam Meningkatkan Pengetahuan Dan Sikap Kesadaran Gizi 3(3):69–70.
Maulina, Lena, and Nining Sugihartini. 2015. “Formulasi Gel Ekstrak Etanol Kulit Buah Manggis (Garcinia Mangostana L.) dengan Variasi Gelling Agent sebagai Sediaan Luka Bakar.” Pharmaciana 5(1):43–52.
Nanda, Y., Nur M. Salim, and Cut D. Iskandar. 2017. “Hispatologi Kulit Mencit (Mus Musculus) Fase Remodeling Pada Penyambuhan Luka Sayat Dengan Salep Getah Jarak Pagar (Jatropha Curcas Linn).” Jurnal Ilmiah Mahasiswa Veteriner 01(4):780–87.
Nugroho, Agung Endro. 2020. “Garcinia Mangostana Mangosteen.” Biotechnology of Fruit and Nut Crops 154–63.
Ovalle-Magallanes, Berenice, Dianelena Eugenio-Pérez, and José Pedraza-Chaverri. 2017. “Medicinal Properties of Mangosteen (Garcinia Mangostana L.): A Comprehensive Update.” Food and Chemical Toxicology 109:102–22.
Parmita, Risci Intan, Muhammad In, and Ita Armyanti. 2017. “Uji Efek Antiinflamasi Kombinasi Astaxanthin Dan Ekstrak Kulit Manggis ( Garcinia Mangostana Linn ) Pada Tikus Putih Galur Wistar Abstrak PENDAHULUAN Inflamasi Merupakan Suatu Respon Protektif Yang Ditujukan Drug / NSAID ) Namun Memiliki Efek Samping Yang.” 3:689–96.
Puspitaningrum, Ika, Lia Kusmita, and Wahyuning Setyani. 2014. “Efek Analgetik Antipiretik Ekstrak Etanol Kulit Buah Manggis (Garcinia Mangostana L.) Pada Tikus Putih Jantan Galur Wistar.” E-Publikasi Ilmiah Fakultas Farmasi Unwahas Semarang 11(1):18–24.
Putra SR. 2012. Rahasia-Rahasia Keajaiban Kulit Buah Manggis. Cetakan 1. Jogjakarta: Diva Press.
Putri, Gemonia Ananda. 2020. “Pada Penyembuhan Luka Soket Pasca Pencabutan Gigi Tikus Putih Galur Wistar ( Rattus Novergicus ) Secara Hematoxilin Eosin ( He ) Universitas Sumatera Utara Medan 2020.”
Putri, W. S., N. K. Warditiani, and L. P. F. Larasanty. 2013. “Skrining Fitokimia Ekstrak Etil Asetat Kulit Buah Manggis ( Garcinia Mangostana L .).” Journal Pharmacon 09(4):56–59.
Riskesdas. 2013. Riskesdas.
Sorongan, Ryan Stefanus, and Krista V Siagian. 2015. “Efektivitas Perasan Daun Pepaya Terhadap Aktivitas Fibroblas Pasca Pencabutan Gigi Pada Tikus Wistar Jantan.” Pharmacon 4(4):52–57.
Sugiaman, Vinna K. 2011. “Peningkatan Penyembuhan Luka Di Mukosa Oral Melalui Pemberian Aloe Vera ( Linn .) Secara Topikal Topical.” Maranatha Journal of Medicine and Health 11(1):70–79.
Sumbayak, Erma Mexcorry. 2015. “Tinjauan Pustaka Fibroblas : Struktur Dan Peranannya Dalam Penyembuhan Luka.” Jurnal Kedokteran Meditek 21(6):1–6.
Suryadi, Iwan Antara. 2013. “Wound Healing Process and Wound Care.” E-Jurnal Medika Udayana 2(2):254–72.
Wehantouw, Frenly, and Sondang Manurung. 2011. “Aktivitas Antihiperglikemik Ekstrak Kulit Manggis (Garcinia Mangostana L.) pada Tikus yang Diinduksi Sukrosa.” Chemistry Progress 4(2):89–96.
Yanti, Dharma. 2021. “Perbandingan Aktivitas Antioksidan Dan Toksisitas Antara Daging Buah, Kulit Bagian Dalam Dan Kulit Bagian Luar Buah Manggis (Garcinia Mangostana L.).” Jurnal Ayurveda Medistra 3(1):27–34.
Yulia, Avira Rizqiana. 2013. “Pengaruh Ekstrak Kulit Buah Manggis (Garcinia Mangostana L.) terhadap Jumlah Fibroblas pada Gingiva Tikus Wistar Jantan Pasca Induksi Porphyromonas Gingivalis.” Fakultas Kedokteran Gigi Universitas Jember (Skripsi):14–27.
DOI: https://doi.org/10.33258/birex.v4i1.3473
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