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Resilience State Security and the Role Sedative Agents in Military Pharmacy for State Defense in Future War
Abstract
National defense is closely related to the role of an intelligence officer who is strong and capable of safeguarding the country's sovereignty. Intelligence covers many fields. One of those is medical intelligence. Mitragynine can be used as a sedative agent in a medical intelligence operation. To analyze a sedative agent in intelligent medical purposing of military aspect. This paper determines the role of Military Pharmacy in medical intelligence to support national defense using natural substances that contain a sedative agent. This research used narrative review method for this study obtained from Crossref, google scholar, PubMed, and Scopus range 2010 to 2021 in the English language, using the following terms: "National defense," "Medical intelligence," "Kratom" Mitragynine "Sedative agent" but we did not exclude out older works that were often cited and significant. Mitragynine binds to three types of receptors with varying affinities, with the highest affinity for μ, K, and δ-opioid receptors, which can be used as sedatives in medical intelligence to support national defense. Kratom is a plant endemic to Southeast Asia; this plant has a sedative effect at high doses. Kratom leaves contain thirty-seven alkaloid compounds. Both alkaloid compounds are Mitragynine and 7-hydroxymitragynine, both of which are included in the indole alkaloid compound, the main kratom compound. Plants that are used when facing the battlefield in maintaining national defense are very complex owned by the Indonesian state, that is the kratom plant which has a chance to strengthening people defense and security state facing of sixth generation war. This study needs to validate with more rigorous human clinical studies in the future.
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Akbar, S. (2020). Handbook of 200 Medicinal Plants: A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications. Handbook of 200 Medicinal Plants.
Anderson, P. D. (2012). Bioterrorism: toxins as weapons. Journal of Pharmacy Practice, 25(2), 121–129. https://doi.org/10.1177/0897190012442351
Anwar, S. (2014). The Role of Defence Diplomacy in Coping with Challenges in the Field of Defence. Jurnal Pertahanan Agustus, 4(2), 71.
Aritonang, S., Yulieanto, H., & Rajab, D. D. A. (2018). Jurnal Pertahanan. Jurnal Pertahanan, 4(1), 61–75. http://jurnal.idu.ac.id/index.php/DefenseJournal/article/view/253/pdf4
Babu, K. M., McCurdy, C. R., & Boyer, E. W. (2008). Opioid receptors and legal highs: Salvia divinorum and Kratom. Clinical Toxicology, 46(2), 146–152. https://doi.org/10.1080/15563650701241795
Coleman, C. N., Bader, J. L., Koerner, J. F., Hrdina, C., Cliffer, K. D., Hicks, J. L., James, J. J., Mansoura, M. K., Livinski, A. A., Nystrom, S. v., DiCarlo-Cohen, A., Marinissen, M. J., Wathen, L., Appler, J. M., Buddemeier, B., Casagrande, R., Estes, D., Byrne, P., Kennedy, E. M., … Hatchett, R. (2019). HHS Public Access Author manuscript Disaster Med Public Health Prep. Author manuscript; available in PMC 2020 July 04. Published in final edited form as: Disaster Med Public Health Prep. 2019 December ; 13(5-6): 995–1010. doi:10.1017/dmp.2018.163. Chemica. Disaster Med Public Health Prep., 13(5–6), 995–1010. https://doi.org/10.1017/dmp.2018.163.Chemical
European Monitoring Centre for Drugs and Drug Addiction. Kratom drug profile. Small Ruminant Research [Internet]. 1994; 14(2):151–9. https://www.emcdda.europa.eu/publications/drug-profiles/kratom_en; Accessed 5 September 2021
Hashem, A. M., Abdel-Ghany, A. E., Abuzeid, H. M., El-Tawil, R. S., Indris, S., Ehrenberg, H., Mauger, A., & Julien, C. M. (2018). EDTA as chelating agent for sol-gel synthesis of spinel LiMn2O4 cathode material for lithium batteries. Journal of Alloys and Compounds, 737, 758–766. https://doi.org/10.1016/j.jallcom.2017.12.153
Indonesia NR, Rahmat D, Yang T, Esa M, Indonesia PR. www.djpp.depkumham.go.id. 1982;
Ismail, I., Wahab*, S., Sidi, H., Das, S., & Razali, L. J. L. and R. (2019). Kratom and Future Treatment for the Opioid Addiction and Chronic Pain: Periculo Beneficium? In Current Drug Targets (Vol. 20, Issue 2, pp. 166–172). https://doi.org/http://dx.doi.org/10.2174/1389450118666170425154120
Kanato, M., & Leyatikul, P. (2017). Effectiveness of Drug Camps in Treatment of Substance Abuse in Thailand. Journal of Community Health, 42(6), 1090–1095. https://doi.org/10.1007/s10900-017-0356-1
Kuay, L.K., et.al. (2021). Methodology of the Evaluation of “Komuniti Sihat Pembina Negara-Plus” (KOSPEN Plus) Programme among Workers in Malaysia (Phase 1). Budapest International Research in Exact Sciences (BirEx) Journal Vol 3 (1):68-76.
Lubis, D.A., et.al. (2021). The Relation between the Characteristics of Parents and the Incidence of Stunting in Elementary School Children in the Working Area of the Air Beliti Health Center. Budapest International Research in Exact Sciences (BirEx) Journal Vol 3 (4): 254-260.
Meireles, V., Rosado, T., Barroso, M., Soares, S., Gonçalves, J., Luís, Â., Caramelo, D., Simão, A., Fernández, N., Duarte, A., & Gallardo, E. (2019). Mitragyna speciosa: Clinical, Toxicological Aspects and Analysis in Biological and Non-Biological Samples. Medicines, 6(1), 35. https://doi.org/10.3390/medicines6010035
Menteri Pertahanan. Peraturan Menteri Pertahanan nomor 19 tahun 2015 tentang kebijakan penyelenggaraan pertahanan negara tahun 2015-2O19. 2016; 2:35.
Najikhah, N., et.al. (2021). Determinants of Complete Basic Immunization in Children Aged 12-23 Months in Indonesia. Budapest International Research in Exact Sciences (BirEx) Journal Vol 3 (4): 304-318.
Octavian, A. (2021). National defense perspective of the COVID-19 pandemic. IOP Conference Series: Earth and Environmental Science, 708(1). https://doi.org/10.1088/1755-1315/708/1/012103
Optimalisasi Kinerja Kon Tra Intelijen Dalam Peng Amanan Rahasia Negara. Vol. 15, Optimalisasi Kinerja KonTra Intelijen Dalam Peng Amanan Rahasia Negara. 2016. p. 17–29.
Ryacudu. (2021). Strengthening Total People’s Defense and Security System in the Industrial Revolution Era 4. 0 To Face. 7(2), 191–204.
Singh, D., Narayanan, S., Grundmann, O., Dzulkapli, E. bin, & Vicknasingam, B. (2019). Effects of Kratom (Mitragyna Speciosa Korth.) Use in Regular Users. Substance Use & Misuse, 54(14), 2284–2289. https://doi.org/10.1080/10826084.2019.1645178
Suhaimi, F. W., Yusoff, N. H. M., Hassan, R., Mansor, S. M., Navaratnam, V., Müller, C. P., & Hassan, Z. (2016). Neurobiology of Kratom and its main alkaloid mitragynine. Brain Research Bulletin, 126, 29–40. https://doi.org/https://doi.org/10.1016/j.brainresbull.2016.03.015
Wilujeng, N. F. (2021). Jurnal Pertahanan Regional Forum (ARF) From the Perspective of. 7(2), 205–216.
DOI: https://doi.org/10.33258/birex.v4i2.4590
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